Curative effect of Semecarpus anacardium Linn. nut milk extract against adjuvant arthritis -- with special reference to bone metabolism

Chemico-biological Interactions
Vanu Ramkumar RamprasathPanchanatham Sachdanandam

Abstract

Localised bone loss in the form of bone erosions and peri-articular osteopenia constitutes an important criteria for the diagnosis of rheumatoid arthritis. In the present study, the effect of Semecarpus anacardium Linn. nut milk extract (SA) on the metabolism of bone turn over has been studied by analyzing various markers of bone turnover and by histological and radiological analysis of the joints in adjuvant arthritis in rats. Arthritis was induced in rats by injecting Freund's complete adjuvant containing 10mg of heat killed mycobacterium tuberculosis in 1 ml paraffin oil (0.1 ml) into the left hind paw of the rat intradermally. After 14 days of induction, SA (150 mg/kg body weight/day) was administered orally by gastric intubations for 14 days. SA significantly reverted the alterations in the bone turnover observed in arthritic animals by modulating the levels of calcium, phosphorus and the activities of the enzymes names tartrate resistant acid phosphatase, acid phosphatase and alkaline phosphatase. The drug increased the bone weights that were found to be decreased during arthritis. Protective effect of SA was also observed by the decrease in the levels and expression of tumour necrosis factor alpha (TNF-alpha) as well as ...Continue Reading

References

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Citations

May 16, 2013·Journal of Materials Science. Materials in Medicine·Ning ChengBin Shi
Nov 1, 2008·BMC Complementary and Alternative Medicine·Letizia PenolazziRoberto Gambari
May 12, 2009·Journal of Ethnopharmacology·P K Raveedran NairCheppail Ramachandran
Sep 3, 2009·Annals of the New York Academy of Sciences·Roberta PivaRoberto Gambari
Sep 28, 2010·Journal of Cellular Biochemistry·France VaillancourtMohamed Benderdour
Jul 30, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mani RenukaArumugam Ramakrishnan
Jul 1, 2017·Journal of Evidence-based Complementary & Alternative Medicine·Seyed Mohammad Hosseini KasnaviehLatif Gachkar
Oct 28, 2017·Chemico-biological Interactions·Ju Ri HamMi-Kyung Lee

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