Curative effects of interferon-alpha and HLA-DRB1 -DQA1 and -DQB1 alleles in chronic viral hepatitis B

World Journal of Gastroenterology : WJG
Guo-Qing ZangZheng-Hao Tang

Abstract

To investigate the association between curative effects of interferon-alpha and partial human leucocyte antigen (HLA) II alleles in chronic viral hepatitis B. Sixty patients with chronic viral hepatitis B in Shanghai were treated with a standard course of treatment with interferon-alpha for 6 mo. HLA-DRB1, -DQA1, and -DQB1 alleles were detected by polymerase chain reaction-sequence specific primer (PCR-SSP) method. Frequencies of HLA-DRB1*04 (P<0.025) and HLA-DQA1*0303 (P<0.01) in non-responders were significantly higher than those in partial and complete responders. Frequencies of HLA-DQA1*0505 (P<0.025) and HLA-DQB1*0301 (P<0.005) in partial and complete responders were significantly higher than those in non-responders. Non-response to interferon-alpha therapy is positively correlated with HLA-DRB1*04 and HLA-DQA1*0303, and negatively correlated with HLA-DQA1*0505 and -DQB1*0301 in patient with chronic viral hepatitis B. HLA II genes of the identification alleles provide a method for evaluating outcome of interferon-alpha treatment.

References

Jan 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J van HattumS W Schalm
Jun 1, 1995·The New England Journal of Medicine·M J TongR L Co
Apr 20, 1995·The New England Journal of Medicine·M R ThurszA V Hill
Mar 1, 1997·Journal of Hepatology·T HöhlerC Rittner
Mar 29, 2002·Kidney International·Rajendra BhimmaCatherine A Connolly
Oct 17, 2003·World Journal of Gastroenterology : WJG·Ye-Gui JiangJun Liu

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Citations

Feb 20, 2018·Journal of Clinical Laboratory Analysis·Yingying WuQishui Ou

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