Curative vs palliative strategies in locoregional recurrence of gastrointestinal malignancies

Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen
J R SiewertR Rosenberg

Abstract

Locoregional recurrence is a relevant problem in surgical oncology. Intraluminal local relapse only occurs when the primary resection is carried through with inappropriate safety margins. If possible, a second surgical resection with wider margins is the treatment of choice. When the primary resection was appropriately done, extraluminal relapse in the original tumor bed indicates the primary tumor was already in an advanced stage. The indication for a second resection must be considered carefully. A realistic prospect of long-term tumor control exists only when the second resection yields tumor-free margins and is combined with chemo- and radiotherapy. There is usually no curative treatment option for recurrences in the draining lymph node region, the so-called fourth dimension.

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Citations

Nov 23, 2006·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·J R Siewert, F Lordick
Jan 15, 2011·Langenbeck's Archives of Surgery·Katja OttMarkus Büchler
Nov 14, 2013·World Journal of Gastroenterology : WJG·Federico CoccoliniFausto Catena
Sep 17, 2009·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·K Ott, F Lordick
Aug 13, 2008·Expert Opinion on Biological Therapy·Florian LordickDirk Jäger
Apr 8, 2011·The Journal of Surgical Research·Manfred G KrukemeyerWolfgang Wagner
Sep 29, 2011·Annals of the New York Academy of Sciences·Srinadh KomanduriHubert Stein

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