Curcumin alleviates lipopolysaccharide-induced neuroinflammation in fetal mouse brain

Restorative Neurology and Neuroscience
Hongyan ChenHong Jiang

Abstract

Curcumin exerts multiple functions including antioxidant and anti-inflammation, and has been shown protective potential on neurological disorders. Maternal or intrauterine infection/inflammation is one of the major factors underlying perinatal brain damage. This study aimed to determine whether maternal administration of curcumin has attenuation on neuroinflammation in fetal brain caused by lipopolysaccharide (LPS) administration. LPS was used to establish mouse fetal brain injury model, and we investigated the effects of curcumin (40 mg/kg) on the fetal mouse brain by evaluating the morphological change of the neuronal cells and the expression of different pro-inflammatory cytokines and chemokines at protein and mRNA levels in the fetal brains, the maternal serum and amniotic fluid. Our results demonstrated that maternal administration of curcumin has attenuation on neuroinflammation in the fetal brain induced by LPS. Pretreatment of curcumin in the LPS-induced mice effectively reestablished the neuronal cell morphology, attenuated the expression of soluble intercellular adhesion molecule-1, sE-Selectin, macrophage chemoattractant protein-1 and cytokine-induced neutrophil chemoattractant-1 in the maternal serum, decreased the ...Continue Reading

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Citations

Sep 23, 2020·American Journal of Perinatology·Tania Siahanidou, Christina Spiliopoulou
Apr 6, 2019·Neurotoxicity Research·Faezeh GhasemiAmirhossein Sahebkar
Jan 23, 2021·Antioxidants·Giovanni TossettaDaniela Marzioni

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