Curcumin Ameliorates Heat-Induced Injury through NADPH Oxidase-Dependent Redox Signaling and Mitochondrial Preservation in C2C12 Myoblasts and Mouse Skeletal Muscle.

The Journal of Nutrition
Tianzheng YuPatricia A Deuster

Abstract

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and the mitochondrial electron transport chain are the primary sources of reactive oxygen species (ROS). Previous studies have shown that severe heat exposure damages mitochondria and causes excessive mitochondrial ROS production that contributes to the pathogenesis of heat-related illnesses. We tested whether the antioxidant curcumin could protect against heat-induced mitochondrial dysfunction and skeletal muscle injury, and characterized the possible mechanism. Mouse C2C12 myoblasts and rat flexor digitorum brevis (FDB) myofibers were treated with 5 μM curcumin; adult male C57BL/6J mice received daily curcumin (15, 50, or 100 mg/kg body weight) by gavage for 10 consecutive days. We compared ROS levels and mitochondrial morphology and function between treatment and nontreatment groups under unheated or heat conditions, and investigated the upstream mechanism and the downstream effect of curcumin-regulated ROS production. In C2C12 myoblasts, curcumin prevented heat-induced mitochondrial fragmentation, ROS overproduction, and apoptosis (all P < 0.05). Curcumin treatment for 2 and 4 h at 37°C induced increases in ROS levels by 42% and 59% (dihydroethidium-derived fluores...Continue Reading

References

Dec 1, 2001·Free Radical Biology & Medicine·J Nordberg, E S Arnér
Aug 20, 2005·Free Radical Biology & Medicine·Atanu BarikK Indira Priyadarsini
Feb 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Tianzheng YuYisang Yoon
Jun 14, 2006·Molecular and Cellular Biochemistry·Manikandan PanchatcharamLonchin Suguna
Jun 17, 2006·The EMBO Journal·Naotada IshiharaKatsuyoshi Mihara
Jan 24, 2007·Physiological Reviews·Karen Bedard, Karl-Heinz Krause
Jan 8, 2008·Biochimica Et Biophysica Acta·A KunwarK I Priyadarsini
Nov 13, 2008·Cytotechnology·Maria AgnelloAnna Maria Rinaldi
Nov 14, 2008·American Journal of Physiology. Cell Physiology·Isabella IrrcherDavid A Hood
May 14, 2010·Journal of Alzheimer's Disease : JAD·Blaise BossyElla Bossy-Wetzel
Jun 4, 2010·Antioxidants & Redox Signaling·Yisang YoonTianzheng Yu
Jan 31, 2012·Cellular Signalling·Paul D RayYoshiaki Tsuji
May 15, 2012·Biochimica Et Biophysica Acta·Luiza K Sanjuán Szklarz, Luca Scorrano
Aug 8, 2012·Antioxidants & Redox Signaling·Tim-Christian ZschauerJudith Haendeler
Sep 1, 2012·Science·Richard J Youle, Alexander M van der Bliek
Sep 25, 2012·Free Radical Biology & Medicine·Claude A Piantadosi, Hagir B Suliman
Jan 5, 2014·Antioxidants & Redox Signaling·Sebastian AltenhöferHarald H H W Schmidt
Feb 13, 2014·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Sahdeo PrasadBharat B Aggarwal
Feb 25, 2014·Cell Metabolism·Jeanho Yun, Toren Finkel
Mar 13, 2014·The Journal of Cell Biology·Ruchika AnandThomas Langer
May 23, 2014·Current Biology : CB·Michael Schieber, Navdeep S Chandel
May 24, 2014·Nature Reviews. Molecular Cell Biology·Kira M Holmström, Toren Finkel
Jul 6, 2014·Physiological Reviews·Dmitry B ZorovSteven J Sollott
Oct 25, 2014·The Journal of Biological Chemistry·Tianzheng YuYisang Yoon
Jan 2, 2015·Frontiers in Bioscience (Landmark Edition)·Tianzheng YuYisang Yoon
Jan 16, 2015·Redox Biology·Helmut Sies
Jul 15, 2015·Cell Metabolism·Peter H G M WillemsWerner J H Koopman
Sep 19, 2015·Journal of Athletic Training·Douglas J CasaSusan W Yeargin
Dec 8, 2015·Experimental and Therapeutic Medicine·Donatella PerroneLorenzo Lo Muzio
Feb 21, 2016·Journal of Cellular Physiology·Yuhui YangAlexandr V Bazhin
May 18, 2016·Free Radical Biology & Medicine·Leonardo F Ferreira, Orlando Laitano
Oct 23, 2016·British Journal of Pharmacology·Ajaikumar B KunnumakkaraBharat B Aggarwal
Jan 12, 2017·Journal of Medicinal Chemistry·Kathryn M NelsonMichael A Walters
Apr 26, 2017·Annual Review of Biochemistry·Helmut SiesDean P Jones
Jan 3, 2018·FEBS Letters·Plamena R Angelova, Andrey Y Abramov
Feb 1, 2018·Biochimica Et Biophysica Acta. Bioenergetics·Valentina Del DottoClaudia Zanna

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis