Nov 14, 2019

Curcumin Ameliorates Nonalcoholic Fatty Liver Disease through Inhibition of O -GlcNAcylation

Nutrients
Da Eun LeeOh-Shin Kwon

Abstract

The cause of progression to non-alcoholic fatty liver disease (NAFLD) is not fully understood. In the present study, we aimed to investigate how curcumin, a natural phytopolyphenol pigment, ameliorates NAFLD. Initially, we demonstrated that curcumin dramatically suppresses fat accumulation and hepatic injury induced in methionine and choline-deficient (MCD) diet mice. The severity of hepatic inflammation was alleviated by curcumin treatment. To identify the proteins involved in the pathogenesis of NAFLD, we also characterized the hepatic proteome in MCD diet mice. As a result of two-dimensional proteomic analysis, it was confirmed that thirteen proteins including antioxidant protein were differentially expressed in hepatic steatosis. However, the difference in expression was markedly improved by curcumin treatment. Interestingly, eight of the identified proteins are known to undergo O-GlcNAcylation modification. Thus, we further focused on elucidating how the regulation of O-linked β-N-acetylglucosamine (O-GlcNAc) modification is associated with the progression of hepatic steatosis leading to hepatitis in MCD diet mice. In parallel with lipid accumulation and inflammation, the MCD diet significantly up-regulated hexosamine bios...Continue Reading

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Mentioned in this Paper

superoxide dismutase 1
Study
SIRT1 protein, human
SIRT1
Diet
Pathogenesis
Regulation of Biological Process
Hepatitis
Fatty Liver
Nonalcoholic Steatohepatitis

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