Curcumin and Rutin Down-regulate Cyclooxygenase-2 and Reduce Tumor-associated Inflammation in HPV16-Transgenic Mice

Anticancer Research
Magda MoutinhoRui M Gil da Costa

Abstract

Cyclo-oxygenase-2 (COX2) plays a prominent role in carcinogenesis. This study addresses the effects of two nutraceutical compounds on the expression of COX2 and tumor-associated inflammation in human papillomavirus type 16 (HPV16)-transgenic mice. Six-week-old FVB/n mice were supplemented with rutin or curcumin for 24 weeks: HPV16-/-no treatment, n=12; HPV16+/-no treatment, n=13; HPV16+/-rutin, n=12; HPV16+/-curcumin, n=13. HPV16-induced skin lesions and their inflammatory infiltrates were studied histologically. COX2 expression was assessed immunohistochemically. Rutin reduced COX2 expression in the dermis (immunostaining score 7.83 versus 11.25 in untreated HPV16-transgenic mice) and epidermis (4.5 versus 10.0). Curcumin led to dermal and epidermal scores of 10.5 and 4.5. Both compounds reduced leukocytic infiltration, but neither prevented epidermal dysplasia. COX2 expression in HPV16-induced lesions may be modulated by nutraceuticals, reducing tumor-associated inflammation. However, this was not sufficient to block carcinogenesis, calling for additional studies focused on combination therapies.

Citations

Aug 14, 2019·International Journal of Molecular Sciences·Tiago FerreiraPaula Alexandra Oliveira
Oct 16, 2020·Critical Reviews in Food Science and Nutrition·Arakkaveettil Kabeer FarhaHarold Corke
Aug 28, 2021·International Journal of Molecular Sciences·Georgiana DrețcanuZorița Diaconeasa

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