Curcumin-artemisinin combination therapy for malaria.

Antimicrobial Agents and Chemotherapy
Dalavaikodihalli Nanjaiah NandakumarGovindarajan Padmanaban

Abstract

Artemisinin and curcumin show an additive interaction in killing Plasmodium falciparum in culture. In vivo, 3 oral doses of curcumin following a single injection of alpha,beta-arteether to Plasmodium berghei-infected mice are able to prevent recrudescence due to alpha,beta-arteether monotherapy and ensure almost 100% survival of the animals.

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