Curcumin Attenuates Both Acute and Chronic Immune Nephritis

International Journal of Molecular Sciences
Tianfu WuChandra Mohan

Abstract

Curcumin is known to have immunomodulatory potential in addition to anti-oxidant, anti-inflammatory and anti-carcinogenic effects. The aim of the present study is to investigate the therapeutic effects of curcumin on immune-mediated renal disease in an anti-glomerular basement membrane (GBM) model (representing acute kidney Injury, AKI) and murine lupus model (representing chronic kidney disease, CKD). In the AKI model, female anti-GBM 129/svj mice were administered with curcumin right before disease induction. In the CKD model, female MRL.lpr mice at the age of 8-10 weeks old were treated with curcumin or placebo via oral gavage daily for two months. After treatment, serum autoantibody levels, splenomegaly and spleen cellularity were reduced in murine lupus. Collectively, curcumin ameliorated kidney disease in the two mouse models with either acute or chronic nephritis, as marked by reduced proteinuria, blood urea nitrogen, glomerulonephritis, crescent formation, tubule-interstitial disease, and renal infiltration by lymphocytes. In addition, curcumin treatment reduced activation of the NFkB, MAPK, AKT and pBAD pathways either systemically, or within the inflamed kidneys. These findings suggest that natural food supplements co...Continue Reading

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Citations

Oct 2, 2020·International Journal of Molecular Sciences·Laura Marinela Ailioaie, Gerhard Litscher

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Methods Mentioned

BETA
flow cytometry
histone acetylation
biopsy
urine samples collection
light microscopy

Software Mentioned

ImageJ
Graphpad Instat
GraphPad
ImageQuant

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