Curcumin attenuates cerebral ischemia injury in Sprague-Dawley rats and PC12 cells by suppressing overactivated autophagy

Journal of Photochemistry and Photobiology. B, Biology
Yan ZhangJianliang Fu

Abstract

The present study assessed whether the protective effects of curcumin against cerebral ischemia injury were due to the suppression of overactivated autophagy. Curcumin is a well-known natural polyphenolic compound that effectively counteracts oxidation, inflammation, and various types of cancer. Several studies have demonstrated the protective effects of curcumin against ischemia-reperfusion injury in tissues from the lungs, cardiomyocytes, and liver. The present study employed brain injury models induced by middle cerebral artery occlusion (MCAO) in rats and PC12 oxygen-glucose-deprived (OGD) cells. Infarct area, neurological score, lactate dehydrogenase (LDH) activity, autophagy expression, cell apoptosis, and mRNA and protein expressions of caspase-3 were determined following curcumin supplementation. Compared to MCAO rats, curcumin-treated MCAO rats exhibited substantial reductions in neurological score, infarct area, and LDH activity. MCAO also increased LC3 II/I protein expression and decreased p62 protein expression, but curcumin supplementation significantly reversed these altered protein expressions. Caspase-3 protein expression increased by 46.2% in the MCAO group, but curcumin supplementation significantly reduced th...Continue Reading

Citations

Jan 1, 2019·The International Journal of Neuroscience·Hongzhi ZhouXia Chen
Dec 6, 2019·IUBMB Life·Fatemeh ForouzanfarAmirhossein Sahebkar
Mar 4, 2020·Journal of Biochemical and Molecular Toxicology·Kabeer AbubakarMd Zuki Abu Bakar Zakaria
Dec 14, 2018·International Journal of Molecular Sciences·Ryszard PlutaStanisław J Czuczwar
Jan 18, 2020·International Journal of Molecular Sciences·Marzena Ułamek-KoziołRyszard Pluta
May 11, 2021·Frontiers in Pharmacology·Qian XieDaoyin Gong
Jul 13, 2021·ACS Chemical Neuroscience·Lalita Subedi, Bhakta Prasad Gaire
Jul 11, 2021·Neuroscience and Biobehavioral Reviews·Giuseppe AnnunziataSeyed Mohammad Nabavi
Jul 18, 2021·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Bayarmaa KhadankhuuYunman Li
Aug 14, 2021·Acta Pharmaceutica Sinica. B·Anil AhsanXiangnan Zhang

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