Curcumin attenuates chronic intermittent hypoxia-induced brain injuries by inhibiting AQP4 and p38 MAPK pathway

Respiratory Physiology & Neurobiology
Bo WangWei Wang

Abstract

Chronic intermittent hypoxia (CIH) is one of the main features of obstructive sleep apnea (OSA), which is also commonly associated with neurocognitive impairments. The present study aimed to elucidate the beneficial effect of curcumin on CIH-induced brain injuries. Male balb/c mice (6 ∼ 8 weeks) were exposed to normoxia or a pattern of CIH (8 h/day, cycles of 180 s each, hypoxia: 5% O2 for 50 s, reoxygenation: 21% O2 for 50 s) for 10 weeks, along with daily curcumin treatment (50, 100, or 200 mg/kg, intragastrically) or its vehicle. The results showed that CIH induced significant brain edema, as well as neuronal apoptosis and astrogliosis in the cerebral cortex, brainstem, and cerebellum regions of brain. In addition, increased astrocytic AQP4 expression and activation of p38 MAPK pathway were observed after CIH exposure. Curcumin dose-dependently mitigated the brain edema and relevant cell alterations, showing a neuroprotective effect in CIH-induced brain injury. Together, these results suggest curcumin ameliorates the CIH-induced brain injuries, including brain edema, neuronal death and astrogliosis. The beneficial role of curcumin is mediated partially by regulating AQP4 and p38 MAPK pathway.

Citations

May 28, 2020·Pharmacological Reports : PR·Samira EghbaliferizAmirhossein Sahebkar
Aug 25, 2020·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Jia LiYong-Sheng Wang
May 14, 2019·BioMed Research International·Sumate Ampawong, Natthanej Luplertlop
Apr 3, 2019·International Journal of Molecular Sciences·Mohammed Abir-AwanRoslyn M Bill
Jul 9, 2020·Therapeutic Advances in Chronic Disease·Sophie MoulinElise Belaidi
Dec 23, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Laetitia S GasparAlexandrina Ferreira Mendes

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