Curcumin Attenuates Gentamicin-Induced Kidney Mitochondrial Alterations: Possible Role of a Mitochondrial Biogenesis Mechanism

Evidence-based Complementary and Alternative Medicine : ECAM
Mario Negrette-GuzmánJosé Pedraza-Chaverri

Abstract

It has been shown that curcumin (CUR), a polyphenol derived from Curcuma longa, exerts a protective effect against gentamicin- (GM-) induced nephrotoxicity in rats, associated with a preservation of the antioxidant status. Although mitochondrial dysfunction is a hallmark in the GM-induced renal injury, the role of CUR in mitochondrial protection has not been studied. In this work, LLC-PK1 cells were preincubated 24 h with CUR and then coincubated 48 h with CUR and 8 mM GM. Treatment with CUR attenuated GM-induced drop in cell viability and led to an increase in nuclear factor (erythroid-2)-related factor 2 (Nrf2) nuclear accumulation and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) cell expression attenuating GM-induced losses in these proteins. In vivo, Wistar rats were injected subcutaneously with GM (75 mg/Kg/12 h) during 7 days to develop kidney mitochondrial alterations. CUR (400 mg/Kg/day) was administered orally 5 days before and during the GM exposure. The GM-induced mitochondrial alterations in ultrastructure and bioenergetics as well as decrease in activities of respiratory complexes I and IV and induction of calcium-dependent permeability transition were mostly attenuated by CUR. Prot...Continue Reading

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Citations

Jun 2, 2016·Canadian Journal of Physiology and Pharmacology·Sasivimon PromsanAnusorn Lungkaphin
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Sep 2, 2017·Scientific Reports·Jindao WuDaorong Hou
Sep 18, 2021·Journal of Cellular and Molecular Medicine·Ling LiJingping Liu

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Methods Mentioned

BETA
nuclear translocation
ISS
electron microscopy

Software Mentioned

Prism
GraphPad

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