Curcumin Attenuates Lipopolysaccharide-Induced Hepatic Lipid Metabolism Disorder by Modification of m6 A RNA Methylation in Piglets.

Lipids
Na LuXiang Zhong

Abstract

N6 -methyladenosine (m6 A) regulates gene expression and affects cellular metabolism. In this study, we checked whether the regulation of lipid metabolism by curcumin is associated with m6 A RNA methylation. We investigated the effects of dietary curcumin supplementation on lipopolysaccharide (LPS)-induced liver injury and lipid metabolism disorder, and on m6 A RNA methylation in weaned piglets. A total of 24 Duroc × Large White × Landrace piglets were randomly assigned to control, LPS, and CurL (LPS challenge and 200 mg/kg dietary curcumin) groups (n = 8/group). The results showed that curcumin reduced the increase in relative liver weight as well as the concentrations of aspartate aminotransferase and lactate dehydrogenase induced by LPS injection in the plasma and liver of weaning piglets (p < 0.05). The amounts of total cholesterol and triacylglycerols were decreased by curcumin compared to that by the LPS injection (p < 0.05). Additionally, curcumin reduced the expression of Bcl-2 and Bax mRNA, whereas it increased the p53 mRNA level in the liver (p < 0.05). Curcumin inhibited the enhancement of SREBP-1c and SCD-1 mRNA levels induced by LPS in the liver. Notably, dietary curcumin affected the expression of METTL3, METTL14,...Continue Reading

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Citations

Sep 3, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Jiamin WuXiang Zhong
Jul 8, 2020·Epigenetics : Official Journal of the DNA Methylation Society·Terisha GhaziAnil A Chuturgoon
Sep 17, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Ruifan Wu, Xinxia Wang
Mar 31, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhending GanXiang Zhong
Apr 17, 2020·Animals : an Open Access Journal From MDPI·Jiamin WuXiang Zhong
Sep 29, 2018·The Pharmacogenomics Journal·Xingbo MoHuan Zhang
Jan 24, 2021·Applied Biochemistry and Biotechnology·Xiaojin YangDesheng Xie
Nov 8, 2020·Genomics, Proteomics & Bioinformatics·Yuhuan LiWei Li
Apr 25, 2020·Journal of Hepatology·Zhicong ZhaoQiang Xia
Feb 23, 2021·Frontiers in Cell and Developmental Biology·Bohan ChengShouzhi Wang
May 13, 2021·Journal of Diabetes Investigation·Mingli Sun, Xinan Zhang
Jun 22, 2021·Frontiers in Cell and Developmental Biology·Jiahui LuoKai Sun
Mar 23, 2021·Molecular Human Reproduction·Zhonglin CaiHongjun Li
Jan 11, 2022·Epigenetics : Official Journal of the DNA Methylation Society·Tomasz PodgorniakJorge Fernandes

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