Curcumin attenuates potassium oxonate-induced hyperuricemia and kidney inflammation in mice

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Yonger ChenShaozhen Hou

Abstract

Current evidences suggest that hyperuricemia is closely related to the overproduction or underexcretion of uric acid (UA). Curcumin (CUR), a natural polyphenol component extracted from the rhizome of Curcuma longa, has been reported to treat various symptoms such inflammation disease, seems to be efficacious in hyperuricemia. In this study, we aimed to investigate the effect of CUR on hyperuricemia and kidney inflammation in hyperuricemic mice. Administration with CUR (20 or 40 mg/kg) or allopurinol (ALL, 5 mg/kg) was given to mice orally one hour later after the injection of potassium oxonate (PO) (300 mg/kg, i.p.) for 14 days. CUR administration decreased the levels of uric acid (UA), creatinine (CRE) and blood urea nitrogen (BUN) in serum. Meanwhile, treatment with CUR effectively inhibited serum and liver xanthine oxidase (XOD) levels, and further renewed normal antioxidant enzymes activities (SOD, GSH-Px), reduced MDA accumulation in serum. Further studies showed that CUR decreased inflammatory cytokines productions (IL-1β, IL-18) in serum, as well as inhibited PO-induced the activation of NLRP3 inflammasome signaling in the kidney. In conclusion, the study revealed that CUR exhibited anti-hyperuricemic and anti-inflammato...Continue Reading

Citations

Sep 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wugang ZhangHaifang Chen
Jul 28, 2020·International Journal of Molecular Sciences·Shaoshi WenTao Wang
Jan 4, 2021·Molecular and Cellular Biochemistry·Li WenPing Fu
Nov 25, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·ShiChun ShenJianLong Sheng
Oct 26, 2020·Basic & Clinical Pharmacology & Toxicology·Ali Saeedi-BoroujeniArash Alghasi
Nov 14, 2020·Food & Function·Naixin LiuXinwang Yang
Jun 17, 2020·Journal of Agricultural and Food Chemistry·Naixin LiuXinwang Yang
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Biswadeep DasAkash Agnihotri

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