Curcumin attenuates sepsis-induced acute organ dysfunction by preventing inflammation and enhancing the suppressive function of Tregs

International Immunopharmacology
Long-wang ChenZhongqiu Lu

Abstract

Sepsis is characterized by the extensive release of cytokines and other mediators. It results in a dysregulated immune response and can lead to organ damage and death. Curcumin has anti-inflammatory properties and immunoregulation functions in various disorders such as sepsis, cancer, rheumatoid arthritis, cardiovascular diseases, lung fibrosis, gallstone formation, and diabetes. This paper investigates the effects of curcumin on immune status and inflammatory response in mice subjected to cecal ligation and puncture (CLP). Inflammatory tissue injury was evaluated by histological observation. Magnetic microbeads were used to isolate splenic CD4+CD25+regulatory T cells (Tregs), and phenotypes were then analyzed by flow cytometry. The levels of Foxp3 were detected by Western blot and real-time PCR and cytokine levels were determined by enzyme-linked immunosorbent assay. We found that the administration of curcumin significantly alleviated inflammatory injury of the lung and kidney in septic mice. The suppressive function of Treg cells was enhanced and the plasma levels of IL-10 increased after treatment with curcumin. Furthermore, the secretion of plasma TNF-α and IL-6 was notably inhibited in septic mice treated with curcumin an...Continue Reading

Citations

Aug 21, 2019·Phytotherapy Research : PTR·Arash KarimiAli Tarighat-Esfanjani
Feb 13, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Saleh A AlmatroodiArshad Husain Rahmani
Nov 21, 2020·BioFactors·Babak AlikiaiiAmirhossein Sahebkar
Apr 13, 2021·Journal of Pharmaceutical Analysis·Donata Pluskota-KarwatkaJan Barciszewski
Jul 9, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yaw-Syan FuChing-Feng Weng
Jan 7, 2022·Cancer·Rama Rao MallaGanji Purnachandra Nagaraju

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