Curcumin Attenuates Testicular Injury in Rats with Streptozotocin-Induced Diabetes

BioMed Research International
Wenliang ZhaJun Li

Abstract

Oxidative damage, inflammation, and apoptosis are the primary features of diabetic testicular damage. Curcumin protects against diabetic testicular injury, but the underlying mechanisms remain obscure. This study examined the effect of curcumin on type 2 diabetes mellitus- (T2DM-) induced testicular injury, oxidative stress, and apoptotic changes. T2DM rats were intraperitoneally injected with 40 mg/kg STZ after being fed a high-fat diet for 8 weeks. One week after STZ injection, 100 or 200 mg/kg curcumin was administered orally to the diabetic rats for 16 weeks. Histological changes in the testes were determined by HE staining. Serum testosterone was measured. Markers of superoxide levels, such as SOD activity and MDA content, and markers of cell death, including the expression of Bax, Bcl-2, and MAPK family members, were measured by molecular biology or immunohistochemical techniques. Degeneration and disruption of seminiferous tubule structure were observed in diabetic rats. Serum testosterone levels were markedly lower in diabetic rats than in control rats. Moreover, testicular apoptosis and Bax expression were much higher in diabetic rats than in control rats. Superoxide generation, the NADP+/NADPH ratio, and NADPH oxidase...Continue Reading

References

May 1, 1993·Journal of Reproduction and Fertility·R J AitkenD Buckingham
Aug 1, 1997·International Journal of Andrology·S Sainio-PöllänenP Pöllänen
Mar 2, 1999·Reviews of Reproduction·A P Sinha Hikim, R S Swerdloff
Sep 2, 2000·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·R S RamsewakM G Nair
May 5, 2007·Human Reproduction·I M AgbajeS E M Lewis
Feb 28, 2008·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·E GuneliN Uysal
Mar 5, 2010·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·M XuY Dai
Dec 15, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mehmet KanterMustafa Erboga
Jul 6, 2012·Molecular and Cellular Biochemistry·Panagiota TsounapiNikolaos Sofikitis
Apr 9, 2013·Circulation·Stephen P GrayKarin A Jandeleit-Dahm
May 16, 2014·Reproductive Sciences·Narayana Kilarkaje, Maie M Al-Bader
Sep 22, 2015·Asian Journal of Andrology·Wei-Yuan KongLin-Lin Zhang
Mar 31, 2016·Biological Trace Element Research·Krishna Prahlad MaremandaG B Jena
Apr 25, 2017·Diabetes Research and Clinical Practice·K OgurtsovaL E Makaroff

❮ Previous
Next ❯

Citations

Feb 11, 2020·Clinical and Experimental Reproductive Medicine·Apichakan SampannangSitthichai Iamsaard
Sep 11, 2019·Andrologia·Supataechasit Yannasithinon, Sitthichai Iamsaard
Mar 19, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Pingping ZhangDongmei Gan
Mar 2, 2021·Clinical and Experimental Reproductive Medicine·Abbas ShahediMajid Pourentezari
Jun 8, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Md Tanvir KabirLotfi Aleya
Aug 7, 2021·Saudi Journal of Biological Sciences·Jozaa Z ALTamimiMohammed Abdo Yahya
Dec 1, 2021·Cell Biochemistry and Function·Pınar Koroglu AydınRefiye Yanardag

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
Assay
protein assay
electrophoresis
MDA

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.