PMID: 20127004Feb 4, 2010Paper

Curcumin blocks migration and invasion of mouse-rat hybrid retina ganglion cells (N18) through the inhibition of MMP-2, -9, FAK, Rho A and Rock-1 gene expression

Oncology Reports
Hui-Ju LinJing-Gung Chung

Abstract

Cancer metastasis involves multiple processes which may complicate clinical management and even lead to death. Matrix metalloproteinases (MMPs) play an important role in cancer cell invasion, metastasis and angiogenesis, depending on whether agents can inhibit MMPs which could lead to inhibition of the migration and invasion of cancer cells. Curcumin, the active constituent of the dietary spice turmeric, has potential for the prevention and therapy of cancer. However, there is no study to address the effects of curcumin on migration and invasion of mouse-rat hybrid retina ganglion cells (N18). This is the first study to explore the anti-migration and -invasion of curcumin in mouse-rat hybrid retina ganglion cells (N18) in vitro. Curcumin exerted a dose- and time-dependent inhibitory effect on the invasion and migration of N18 cells in vitro. Results from Western blotting showed that curcumin inhibited the protein levels of PKC, FAK, NF-kappaB p65 and Rho A leading to the inhibition of ERK1/2, MKK7, COX-2 and ROCK1, respectively, finally causing the inhibition of MMP-2 and -9 for the inhibition of migration and invasion of N18 cells. Moreover, this action was involved in the inhibition of gene expression of MMP-2 and -7, FAK, RO...Continue Reading

Citations

Jun 14, 2012·Cancer Metastasis Reviews·Gary G Meadows
Jan 12, 2016·The Journal of Clinical Investigation·Rocío López-PosadasImke Atreya
Jul 22, 2011·The Journal of Nutritional Biochemistry·Alfeu Zanotto-FilhoJosé Cláudio Fonseca Moreira
May 2, 2014·Journal of Cellular and Molecular Medicine·Feng ZhangShizhong Zheng
Sep 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·Francesca LovatCarlo M Croce
Apr 24, 2012·International Immunopharmacology·Hsiang-Ping LeeChih-Hsin Tang
Jun 15, 2018·Journal of Experimental & Clinical Cancer Research : CR·Yi ZhangGuo-Qing Zang
Oct 12, 2010·Journal of Hematology & Oncology·Anuradha BudhuXin W Wang
Jun 8, 2011·Nature Reviews. Clinical Oncology·Maria Angelica CortezGeorge A Calin
Dec 12, 2012·Archivum Immunologiae Et Therapiae Experimentalis·Ammad Ahmad FarooqiMuhammad Ismail
Oct 31, 2012·Science China. Life Sciences·Xue ZhaoHaitao Zhao

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