Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein.

The Journal of Biological Chemistry
Can ZhangRudolph E Tanzi

Abstract

Alzheimer disease (AD) is a devastating neurodegenerative disease with no cure. The pathogenesis of AD is believed to be driven primarily by amyloid-beta (Abeta), the principal component of senile plaques. Abeta is an approximately 4-kDa peptide generated via cleavage of the amyloid-beta precursor protein (APP). Curcumin is a compound in the widely used culinary spice, turmeric, which possesses potent and broad biological activities, including anti-inflammatory and antioxidant activities, chemopreventative effects, and effects on protein trafficking. Recent in vivo studies indicate that curcumin is able to reduce Abeta-related pathology in transgenic AD mouse models via unknown molecular mechanisms. Here, we investigated the effects of curcumin on Abeta levels and APP processing in various cell lines and mouse primary cortical neurons. We show for the first time that curcumin potently lowers Abeta levels by attenuating the maturation of APP in the secretory pathway. These data provide a mechanism of action for the ability of curcumin to attenuate amyloid-beta pathology.

References

Mar 29, 2001·Physiological Reviews·D J Selkoe
Oct 26, 2002·Science·Dennis J Selkoe
Apr 24, 2004·Science·Marie E EganMichael J Caplan
Jul 2, 2004·The New England Journal of Medicine·Jeffrey L Cummings
Dec 14, 2004·The Journal of Biological Chemistry·Fusheng YangGregory M Cole
May 3, 2005·The Journal of Clinical Investigation·Sam Gandy
Sep 2, 2006·The Journal of Biological Chemistry·Mikko HiltunenRudolph E Tanzi
Jun 16, 2007·Advances in Experimental Medicine and Biology·Bharat B AggarwalHaruyo Ichikawa
Aug 9, 2007·The Journal of Biological Chemistry·Henri J HuttunenDora M Kovacs
Aug 28, 2007·Molecular Neurodegeneration·Can ZhangAleister J Saunders
Apr 18, 2008·The Journal of Pharmacology and Experimental Therapeutics·Aynun N BegumSally A Frautschy
Sep 20, 2008·Nature Reviews. Neuroscience·Lars Bertram, Rudolph E Tanzi
Mar 12, 2009·Combinatorial Chemistry & High Throughput Screening·Christophe AntczakHakim Djaballah

❮ Previous
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Citations

Nov 5, 2011·Expert Reviews in Molecular Medicine·Abdenour BelkacemiCharles Ramassamy
Jan 18, 2011·The Journal of Biological Chemistry·Cesare MancusoEugenio Barone
Sep 13, 2011·Eukaryotic Cell·Steven MinearMartha S Cyert
Sep 28, 2012·Nutrition Journal·Robert A DiSilvestroJoshua Bomser
Oct 1, 2013·Alzheimer's Research & Therapy·Yasuko Kitagishi, Satoru Matsuda
Jun 14, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Anchalee Prasansuklab, Tewin Tencomnao
Oct 8, 2014·Neurochemistry International·Zeynep Sezgin, Yildiz Dincer
Apr 6, 2012·Neurochemical Research·Han-Chang HuangZhao-Feng Jiang
Jun 7, 2012·Expert Opinion on Investigational Drugs·Altaf S DarveshCornelis J Van der Schyf
Jul 23, 2015·Proceedings of the National Academy of Sciences of the United States of America·Xueli ZhangChongzhao Ran
Aug 25, 2015·Oxidative Medicine and Cellular Longevity·Maria LucaCarmela Calandra
Nov 6, 2013·Journal of Receptor and Signal Transduction Research·Han-Chang HuangZhao-Feng Jiang
Apr 17, 2012·Ageing Research Reviews·Kathrin Pallauf, Gerald Rimbach
Apr 23, 2016·The British Journal of Nutrition·Stephanie R Rainey-SmithRalph N Martins
Apr 22, 2017·CNS Neuroscience & Therapeutics·Lan-Xue ZhaoYu Qiu
May 13, 2017·BioFactors·Davide BarrecaSeyed Mohammad Nabavi
Apr 24, 2014·Biochemical and Biophysical Research Communications·Qinru SunHaitao Hu
Dec 17, 2016·Journal of Alzheimer's Disease : JAD·Rina KotaniNoriko Noguchi
Jan 2, 2015·Dose-response : a Publication of International Hormesis Society·Mark P Mattson
Jun 5, 2014·European Journal of Mass Spectrometry·Wojciech OstrowskiRafat Frański
May 9, 2012·Angewandte Chemie·Tuba EsatbeyogluGerald Rimbach
Jan 11, 2013·BioFactors·Adriana MonroySilvestre Alavez
Aug 30, 2014·Molecular Nutrition & Food Research·Viviane L Ndam NgoungoureHermann Schluesener
Sep 29, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bharath Kumar VelmuruganChing-Feng Weng
Dec 28, 2018·Acta Biologica Hungarica·Márta KotormánJános Nemcsók
Jan 18, 2018·Current Neuropharmacology·Ianara Mendonça da CostaFausto Pierdoná Guzen
Jul 23, 2013·Phytotherapy Research : PTR·Touqeer Ahmed, Anwarul-Hassan Gilani
Aug 1, 2013·Molecular Nutrition & Food Research·Sihem DogguiCharles Ramassamy
Nov 26, 2013·Journal of Neuroscience Research·Pengwen WangShucui Jiang
Jan 15, 2018·Journal of Alzheimer's Disease : JAD·P Hemachandra ReddyArubala P Reddy
Sep 6, 2011·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Lewis H Kuller, Oscar L Lopez
Jan 30, 2020·International Journal of Molecular Sciences·Lalita SubediSun Yeou Kim
Jul 9, 2016·Behavioural Pharmacology·Teresa A BarberShawn A Gessay

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