Curcumin delivered through bovine serum albumin/polysaccharides multilayered microcapsules

Journal of Biomaterials Applications
V PaşcalăuC Popa

Abstract

The aim of the paper is to obtain and characterize k-carrageenan-chitosan dual hydrogel multilayers shell BSA gel microcapsules, as a carrier for curcumin, and as a possible antitumoral agent in biological studies. We used the CaCO3 template to synthesize non-toxic CaCO3/BSA particles as microtemplates by coprecipitating a CaCl2 solution that contains dissolved BSA, with an equimolar Na2CO3 solution. The microcapsules shell is assembled through a layer-by-layer deposition technique of calcium cross-linked k-carrageenan hydrogel alternating with polyelectrolite complex hydrogel formed via electrostatic interactions between k-carrageenan and chitosan. After the removal of CaCO3 through Ca(2+) complexation with EDTA, and by a slightly treatment with HCl diluted solution, the BSA core is turned into a BSA gel through a thermal treatment. The BSA gel microcapsules were then loaded with curcumin, through a diffusion process from curcumin ethanolic solution. All the synthesized particles and microcapsules were stucturally characterized by: Fourier Transform Infrared Spectroscopy, UV-Vis Spectrometry, X-ray diffraction, thermal analysis, fluorescence spectroscopy, fluorescence optical microscopy, confocal laser scanning microscopy and ...Continue Reading

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Citations

Aug 5, 2016·Expert Opinion on Drug Delivery·Carla VilelaCarmen S R Freire
Mar 2, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Pulavendran Sivasami, Thiagarajan Hemalatha
Aug 28, 2020·Micromachines·Georgia KastaniaDmitry Volodkin

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Methods Mentioned

BETA
thermal treatment
Confocal Microscopy
X-ray
biopsies
flow-cytometry
differential
Fluorescence Optical Microscopy
optical
light microscopy
fluorescence spectroscopy

Software Mentioned

ZEN LS
GraphPad Prism
GraphPad
ZEN

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