Curcumin down-regulates IL-17A mediated p53-fibrinolytic system in bleomycin induced acute lung injury in vivo

Journal of Cellular Biochemistry
Mahesh M Gouda, Yashodhar P Bhandary

Abstract

Bleomycin (BLM) induced cellular damage causes inflammation in the alveolar compartment and impairment of fibrinolytic system leads to alveolar epithelial cell apoptosis. Here, we describe novel inflammatory pathway associated with p53-fibrinolytic system and apoptosis of alveolar epithelial cells and pharmacological efficiency of curcumin against this action. In the present study we used C57BL/6 mice. The specific dose and time interval of curcumin were analyzed to assess the intervention. Experiments were designed to investigate the IL-17A mediated modulation in the alveolar epithelial cell apoptosis and injury. Various techniques such as Western blot, RT-PCR, Immunohistochemistry were used for this study. We observed that the BLM-induced lung injury and its progression were successfully regulated by the effective dose and time intervention of curcumin. There was also decreased expression of chemokines, p53, and fibrinolytic components such as PAI-1 and increased uPA, uPAR expression, and decreased alveolar epithelial cell apoptosis, which indicates the IL-17A mediated novel inflammatory pathway. It is confirmed that the IL-17A involved in the modulation of p53-fibrinolytic system and epithelial cell apoptosis in BLM induced ...Continue Reading

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Citations

Mar 10, 2020·International Journal of Radiation Biology·Shilpa JohnsonYashodhar P Bhandary
Aug 24, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Sadiya Bi ShaikhYashodhar Prabhakar Bhandary
Sep 27, 2018·Molecular Biology Reports·Mahesh Manjunath GoudaYashodhar Bhandary
May 1, 2020·Molecular and Cellular Biochemistry·Punithavathi DurairajMary Babu
Jun 24, 2020·Molecular Biology Reports·Sadiya Bi ShaikhYashodhar Prabhakar Bhandary
May 29, 2018·Molecular Biology Reports·Mahesh Manjunath GoudaYashodhar Prabhakar Bhandary
Apr 24, 2019·Inflammation·Mahesh Manjunath Gouda, Yashodhar Prabhakar Bhandary
Oct 3, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yu-Qiong HeWan-Sheng Chen
Nov 3, 2020·Food Science & Nutrition·Fatemeh BabaeiHossein Hosseinzadeh
Apr 16, 2021·International Immunopharmacology·M Fathimath MuneesaYashodhar P Bhandary
Aug 8, 2021·International Journal of Molecular Sciences·Shiyi Tan, Shi Chen

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