Curcumin Enhances Radiosensitization of Nasopharyngeal Carcinoma via Mediating Regulation of Tumor Stem-like Cells by a CircRNA Network

Journal of Cancer
Daoqi ZhuQin Fan

Abstract

Circular RNAs (circRNAs) are involved in cancer development via inhibition of miRNAs, which are associated with differentiation, proliferation, migration, and carcinogenicity. Curcumin has antioxidant and anti-cancer properties, and it has also been used as a radiosensitizer. In this study, we explored the potential relationships among curcumin, circRNAs, and nasopharyngeal carcinoma (NPC). We compared the differences in circRNA levels in NPC cell lines after radiotherapy and after treatment with curcumin, using a high-throughput microarray. Further, a circRNA-miRNA-mRNA interaction network between radiation resistance NPC cell lines and tumor stem cells was constructed by applying bioinformatics. Finally, it was demonstrated by reverse transcription-quantitative polymerase chain reaction assay and wound healing assay that curcumin could enhance radiosensitization of NPC cell lines via mediating regulation of tumor stem-like cells by the "hsa_circRNA_102115"-"hsa-miR-335-3p"-"MAPK1" interaction network.

Citations

Nov 26, 2020·Cancer Management and Research·Haitao LiChengkuan Cai
May 18, 2021·Frontiers in Oncology·Panchun LiZhaojian Gong
Jun 19, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Henry A AdeolaRashmi Bhardwaj
Oct 15, 2020·Personalized Medicine·Maria PapatsirouChristos K Kontos

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Methods Mentioned

BETA
circRNA array
Feature Extraction
PCR
fluorescence-activated cell sorting
GTPase
flow cytometry

Software Mentioned

Cytoscape
Arraystar
Cluster
mirpath
MiRanda
limma
SPSS
Agilent Feature Extraction
DIANA
R

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