Curcumin enhances the radiosensitivity of U87 cells by inducing DUSP-2 up-regulation

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Yu QianJun Fei Shao

Abstract

Glioblastoma multiforme (GBM), an aggressive primary brain tumor, is radioresistant and recurs despite aggressive surgery, chemotherapy, and radiotherapy. Curcumin as a potential radiosensitizer has received extensive attention in cancer treatment. To explore an effectiveness of this radiosensitizer for GBM treatment, we evaluated the radiosensitizing effect of curcumin and investigated its potential molecular mechanisms in the human glioma cell line U87. The cytotoxic effects of curcumin on U87 cells were evaluated using the Cell Counting Kit-8 assay, and the radiosensitivity of U87 cells treated with curcumin was accessed by colony information assay. The effects of curcumin on cell proliferation and cell cycle regulation were determined using the 5-ethynyl-2-deoxyuridine incorporation assay and flow cytometry, respectively. Western blotting was applied to determine the effects of curcumin on protein expression of dual-specificity phosphatase-2 (DUSP-2), extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK) as well as phosphorylated ERK and JNK. Curcumin significantly inhibited the proliferation of U87 cells in a dose-and time-dependent manner. Curcumin treatment at the concentrations of 5 µM and 10 M ...Continue Reading

Citations

Apr 12, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Seung Ho BaekKwang Seok Ahn
Jun 3, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hui GuoQiang Fu
Jul 28, 2016·Journal of Cancer Research and Therapeutics·Oana AlexandruAnica Dricu
Nov 4, 2016·Oxidative Medicine and Cellular Longevity·Neil V Klinger, Sandeep Mittal
Jan 18, 2017·Nutrition and Cancer·Wissam Zam, Aziz Khadour
Mar 2, 2018·The Journal of Pharmacy and Pharmacology·Xingzhen ZhangGuangxi Zhai
Jun 15, 2016·World Journal of Clinical Oncology·Vivek Verma
Dec 23, 2015·Biofabrication·Atabak Ghanizadeh TabrizWenmiao Shu
Oct 28, 2019·International Journal of Molecular Sciences·Marco CalvarusoLuigi Minafra
Aug 13, 2017·The Biochemical Journal·Matthias DedobbeleerBernard Rogister
Sep 30, 2015·Current Opinion in Clinical Nutrition and Metabolic Care·Moshe SchafferGil Bar-Sela
Jun 16, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yang LiuXiaoyun Xie
Oct 24, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Larisa RyskalinFrancesco Fornai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban
Yan ZhangJian Chen
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Xiaoli LiHong Zhou
Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Ayman M SalehMohammad Azhar Aziz
© 2021 Meta ULC. All rights reserved