Curcumin exerts anti-inflammatory and vasoprotective effects through amelioration of NFAT-dependent endothelin-1 production in mice with acute Chagas cardiomyopathy

Memórias do Instituto Oswaldo Cruz
Matías HernándezRicardo S Corral

Abstract

The anti-inflammatory and cardioprotective properties of curcumin (Cur), a natural polyphenolic flavonoid isolated from the rhizomes of Curcuma longa, are increasingly considered to have beneficial effects on the progression of Chagas heart disease, caused by the protozoan parasite Trypanosoma cruzi. To evaluate the effects of oral therapy with Cur on T. cruzi-mediated cardiovasculopathy in acutely infected mice and analyse the in vitro response of parasite-infected human microvascular endothelial cells treated with this phytochemical. Inflammation of heart vessels from Cur-treated and untreated infected mice were analysed by histology, with benznidazole (Bz) as the reference compound. Parasitaemia was monitored by the direct method. Capillary permeability was visualised by Evans-blue assay. Myocardial ET-1, IL-6, and TNF-α mRNA expressions were measured by quantitative reverse transcription polymerase chain reaction (qRT-PCR). Microvascular endothelial HMEC-1 cells were infected in vitro with or without addition of Cur or Bz. Induction of the Ca2+/NFAT pathway was assessed by fluorometry, immunoblotting, and reporter assay. Oral Cur therapy of recently infected mice reduced inflammatory cell infiltration of myocardial arteries...Continue Reading

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Citations

Aug 9, 2019·Future Medicinal Chemistry·Bhawana SinghAbhay R Satoskar
Dec 15, 2020·British Journal of Clinical Pharmacology·Fernanda LascanoJaime Altcheh
Jan 16, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ali Mohammad Pourbagher-ShahriSaeed Samargahndian
Nov 20, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michał OtrębaAnna Rzepecka-Stojko
Feb 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michał OtrębaAnna Rzepecka-Stojko

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
transfection
light microscopy
ELISA
nuclear translocation

Software Mentioned

GraphPad Prism

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