Curcumin exerts its antitumor activity through regulation of miR-7/Skp2/p21 in nasopharyngeal carcinoma cells

OncoTargets and Therapy
Shaoyan FengGe-hua Zhang

Abstract

Curcumin, a natural polyphenol compound, exhibits tumor suppressive activity in a wide spectrum of cancers, including nasopharyngeal carcinoma cells. However, the exact molecular mechanisms governing this tumor suppressive activity remain elusive. Multiple studies have revealed that miRNAs are critically involved in tumorigenesis, indicating that targeting miRNAs could be a therapeutic strategy for treating human cancer. In the current study, we set out to determine whether curcumin regulates miR-7 expression in nasopharyngeal carcinoma cells. We found that curcumin inhibited cell growth, induced apoptosis, retarded cell migration and invasion, and triggered cell cycle arrest in the human nasopharyngeal carcinoma cell lines CNE1 and CNE2. Importantly, we observed that curcumin upregulated the expression of miR-7 and subsequently inhibited Skp2, a direct miR-7 target. Our results identified that upregulation of miR-7 by curcumin could benefit nasopharyngeal carcinoma patients.

Citations

Jul 7, 2020·BioMed Research International·Yanling LiuGuiying Xu
Feb 13, 2018·Experimental and Therapeutic Medicine·Dengfeng YeChunshou Wei
Oct 24, 2020·Signal Transduction and Targeted Therapy·Yuanbo KangLei Wang
Aug 3, 2021·Experimental and Therapeutic Medicine·Liang PanJianming Guo
Dec 4, 2021·Frontiers in Cellular and Infection Microbiology·Yuying ChenJunhong Wang

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Methods Mentioned

BETA
Protein Assay
electrophoresis
PCR
transfection
xenograft
X-ray
ubiquitination

Software Mentioned

GraphPad
GraphPad Prism

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