Curcumin in Osteosarcoma Therapy: Combining With Immunotherapy, Chemotherapeutics, Bone Tissue Engineering Materials and Potential Synergism With Photodynamic Therapy.

Frontiers in Oncology
Chunfeng XuYuelian Liu

Abstract

Osteosarcoma is a dominating malignant bone tumor with high mortality due to pulmonary metastases. Furthermore, because of the cancer cell erosion and surgery resection, osteosarcoma always causes bone defects, which means dysfunction and disfigurement are seldom inevitable. Although various advanced treatments (e.g. chemotherapy, immunotherapy, radiotherapy) are coming up, the 5-year survival rate for osteosarcoma with metastases is still dismal. In line with this, the more potent treatments for osteosarcoma are in high demand. Curcumin, a perennial herb, has been reportedly applied in the therapy of various types of tumors via different mechanisms. In vitro, it has also been reported that curcumin can inhibit the proliferation of osteosarcoma cell lines and can be used to repair bone defects. This seems curcumin is a promising candidate in osteosarcoma treatment. However, due to its congenital property like hydrophobicity, and low bioavailability, affecting its anticancer effect, clinical applications of curcumin are highly limited. To enhance its performance in cancer therapies, some synergist approaches with curcumin have emerged. The present review presents some prospective ones (i.e. combinations with immunotherapy, chemo...Continue Reading

References

Jul 1, 1975·Journal of the National Cancer Institute·T J DoughertyD G Boyle
Jan 1, 1992·Photochemistry and Photobiology·B W Henderson, T J Dougherty
Nov 1, 1991·Photochemistry and Photobiology·C S Foote
Aug 1, 1986·Zeitschrift Für Lebensmittel-Untersuchung Und -Forschung·H H TønnesenG B van Henegouwen
Nov 20, 1998·Pathology, Research and Practice·K TriebS Dirnhofer
Mar 24, 2000·The Journal of Surgical Research·M ChurchillM M Bertagnolli
Dec 15, 2000·Current Opinion in Structural Biology·M G Grütter
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stefan S BielackKurt Winkler
Feb 22, 2002·International Journal of Cancer. Journal International Du Cancer·Zhi-Ming ShaoMai Nguyen
Jan 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Toshifumi OzakiStefan S Bielack
May 2, 2003·Nature Reviews. Cancer·Dennis E J G J DolmansRakesh K Jain
Jul 15, 2004·International Journal of Cancer. Journal International Du Cancer·Sita AggarwalBharat B Aggarwal
Apr 2, 2005·Nature Reviews. Immunology·Jacques Banchereau, A Karolina Palucka
Jun 24, 2006·Nature Reviews. Cancer·Ana P CastanoMichael R Hamblin
Sep 1, 1891·Annals of Surgery·W B Coley
Sep 29, 2007·Biochemical Pharmacology·Ajay GoelBharat B Aggarwal
Nov 3, 2007·Cancer Research·Philaretos C KousisSandra O Gollnick
Nov 8, 2007·British Journal of Cancer·L-H WeiB W Henderson
Nov 15, 2007·Molecular Pharmaceutics·Preetha AnandBharat B Aggarwal
Dec 12, 2007·Investigational New Drugs·Denise K WaltersBruno Fuchs
Jan 8, 2008·Biochimica Et Biophysica Acta·A KunwarK I Priyadarsini
Feb 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul A MeyersUNKNOWN Children's Oncology Group
Apr 2, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ana P CastanoMichael R Hamblin
Jun 19, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Shaiju K VareedDean E Brenner
Sep 17, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Nagasuresh Adapala, Marion M Chan
Mar 10, 2010·Cancer Treatment and Research·Giulia Ottaviani, Norman Jaffe
Mar 17, 2010·Clinical Orthopaedics and Related Research·Masanori KawanoHiroyuki Tsuchiya
Mar 23, 2010·Cellular & Molecular Immunology·Sankar BhattacharyyaGaurisankar Sa
Jun 1, 2010·Photodiagnosis and Photodynamic Therapy·Ron R Allison, Claudio H Sibata
Sep 16, 2010·The Journal of Physical Chemistry. B·Anindita MukerjeeZygmunt Gryczynski
Oct 15, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J Ritter, S S Bielack
Mar 23, 2011·Methods in Molecular Biology·Yong-Eun Koo Lee, Raoul Kopelman
Mar 28, 2012·Journal of Experimental & Clinical Cancer Research : CR·Shen-meng GaoKang Yu
Apr 24, 2012·International Immunopharmacology·Hsiang-Ping LeeChih-Hsin Tang
Jul 4, 2012·International Immunopharmacology·Guang-ju ZhaoQiao-meng Qiu
Sep 1, 2012·Nature Reviews. Drug Discovery·Patrick Y Muller, Mark N Milton

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.