Curcumin in VIP-targeted sterically stabilized phospholipid nanomicelles: a novel therapeutic approach for breast cancer and breast cancer stem cells

Drug Delivery and Translational Research
Ece GülçürHayat Onyüksel

Abstract

Breast cancer is a leading cause of cancer deaths among women in the US, with 40 % chance of relapse after treatment. Recent studies outline the role of cancer stem cells (CSCs) in tumor initiation, propagation, and regeneration of cancer. Moreover, it has been established that breast CSCs reside in a quiescent state that makes them more resistant to conventional cancer therapies than bulk cancer cells resulting in tumor relapse. In this study, we establish that CSCs are associated with the overexpression of vasoactive intestinal peptide (VIP) receptors which can be used to actively target these cells. We investigated the potential of using a novel curcumin nanomedicine (C-SSM) surface conjugated with VIP to target and hinder breast cancer with CSCs. Here, we formulated, characterized, and evaluated the feasibility of C-SSM nanomedicine in vitro. We investigated the cytotoxicity of C-SSM on breast cancer cells and CSCs by tumorsphere formation assay. Our results suggest that curcumin can be encapsulated in SSM up to 200 μg/ml with 1 mM lipid concentration. C-SSM nanomedicine is easy to prepare and maintains its original physicochemical properties after lyophilization, with an IC50 that is significantly improved from that of fre...Continue Reading

References

Mar 14, 2001·Breast Cancer Research and Treatment·S DagarH Onyüksel
Aug 8, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·S DagarH Onyüksel
Nov 2, 2001·Nature·T ReyaI L Weissman
Sep 3, 2002·International Journal of Pharmaceutics·Hanne Hjorth TønnesenThorsteinn Loftsson
Mar 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Muhammad Al-HajjMichael F Clarke
May 21, 2003·Genes & Development·Gabriela DontuMax S Wicha
Oct 26, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bharat B AggarwalJanet E Price
May 10, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Andreas G Schätzlein
Dec 21, 2006·Journal of the National Cancer Institute·Tiffany M PhillipsFrank Pajonk
Feb 13, 2007·Nanomedicine : Nanotechnology, Biology, and Medicine·Otilia M KooHayat Onyuksel
Feb 21, 2007·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Beatrice BachmeierUlrich Pfeffer
Apr 5, 2007·Nature Protocols·Vanicha Vichai, Kanyawim Kirtikara
Nov 15, 2007·Molecular Pharmaceutics·Preetha AnandBharat B Aggarwal
May 1, 2008·Journal of the National Cancer Institute·Xiaoxian LiJenny C Chang
May 9, 2008·Cancer Letters·Preetha AnandBharat B Aggarwal
Jul 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Navneet DhillonRazelle Kurzrock
Jul 26, 2008·Nature Nanotechnology·Dan PeerRobert Langer
Nov 18, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Serena Di Cosimo, José Baselga
Nov 22, 2008·Cancer Letters·Hayat OnyükselIsrael Rubinstein
Nov 10, 2009·Breast Cancer Research and Treatment·Madhuri KakaralaMax S Wicha
Dec 4, 2009·Translational Oncology·Yingjie YuAdhip Pn Majumdar
Jan 7, 2010·The Journal of Clinical Investigation·Natasha Y FrankMarkus H Frank
Sep 15, 2010·Nature Reviews. Clinical Oncology·Rakesh K Jain, Triantafyllos Stylianopoulos
Nov 16, 2010·Pharmacology & Therapeutics·Phillip CallihanShelley B Hooks
Nov 26, 2010·Pharmaceutical Research·Sok Bee LimHayat Önyüksel
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
May 7, 2011·Cancer Prevention Research·Shyam S BansalRamesh C Gupta
Jul 26, 2011·Journal of the American Chemical Society·Lela VukovićHayat Onyuksel
Aug 3, 2012·Nature·Gregory DriessensCédric Blanpain
Nov 13, 2012·The AAPS Journal·Subash C GuptaBharat B Aggarwal

❮ Previous
Next ❯

Citations

May 6, 2014·Frontiers in Pharmacology·Aditi M Jhaveri, Vladimir P Torchilin
Sep 10, 2016·Seminars in Cancer Biology·Prasad R DandawateShrikant Anant
Sep 30, 2016·Frontiers in Pharmacology·Lili HeJingxin Mo
Jan 12, 2019·Critical Reviews in Food Science and Nutrition·Hao-Feng GuMin Du
Mar 4, 2021·International Journal of Nanomedicine·Li LvGuocheng Li
Jul 10, 2021·Molecular and Cellular Endocrinology·Yurong Zheng, Antoine E Karnoub

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.