Curcumin inhibits constitutive STAT3 phosphorylation in human pancreatic cancer cell lines and downregulation of survivin/BIRC5 gene expression

Cancer Investigation
W GlienkeL Bergmann

Abstract

The purpose of this study was to determine the effect of curcumin on Survivin/BIRC5 and on the role of signal transducer and activator of transcription 3 (STAT3) activation in Survivin/ BIRC5. We incubated two pancreatic cancer cell lines with different amounts of curcumin. This resulted in a downregulation of proliferation in all cell lines tested. The expression of Survivin/BIRC5 on mRNA and protein level was significantly downregulated and the phosphorylation of STAT3 was blocked. Treatment of pancreatic cancer cells with curcumin resulted in an induction of apoptosis. The results indicate that curcumin inhibits several key factors in cancer cellular pathways and may be of interest in pancreatic cancer.

References

Feb 15, 1997·Lancet·S Rosewicz, B Wiedenmann
Oct 21, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·S S HanS Bondada
Apr 20, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·K MahboubiJ S Pober
Nov 26, 2003·Biochemical Pharmacology·Tzeng-Horng LeuMing-Chei Maa
Mar 23, 2005·Proceedings of the National Academy of Sciences of the United States of America·Hui SongJiayuh Lin
Aug 6, 2005·Biochemical and Biophysical Research Communications·Fu-Chuan HsiehJiayuh Lin
Jan 7, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tanya GritskoRichard Jove
Mar 22, 2006·Best Practice & Research. Clinical Gastroenterology·Albert B Lowenfels, Patrick Maisonneuve
Jun 1, 2006·Cancer Science·Akihiko Yoshimura
Nov 23, 2006·Chemistry & Biology·Jochen SchustThorsten Berg
Jan 30, 2009·Journal of the National Cancer Institute·Ravi P Sahu, Sanjay K Srivastava
Feb 7, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Wolfgang GlienkeLothar Bergmann

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Citations

Nov 1, 2012·Cancer Letters·Srinivas Reddy Boreddy, Sanjay K Srivastava
May 25, 2011·World Journal of Gastrointestinal Pathophysiology·Sigrid A Rajasekaran
Oct 9, 2014·BioMed Research International·Arshad H RahmaniMasood A Khan
Nov 8, 2013·BioMed Research International·Mohammad Zahid KamranRajiv P Gude
Sep 28, 2013·Cancer Prevention Research·Dipali Sharma, Saraswati Sukumar
Jun 10, 2011·Free Radical Research·Bokyung SungBharat B Aggarwal
May 27, 2014·Expert Opinion on Drug Delivery·Wing-Hin LeeRamin Rohanizadeh
Nov 17, 2015·International Journal of Molecular Sciences·Byeong Mo KimYonggeun Hong
Oct 23, 2014·Journal of Cancer Prevention·Ji Hoon Yu, Hyeyoung Kim
Sep 24, 2013·JAK-STAT·Roxane PaulinSébastien Bonnet
Jul 16, 2015·PloS One·Carlos J Diaz OstermanNathan R Wall
May 12, 2015·PloS One·Y Sangeeta DeviAsgerally T Fazleabas
Nov 23, 2016·Critical Reviews in Food Science and Nutrition·Muhammad ImranHafiz Ansar Rasul Suleria
Nov 30, 2016·BioFactors·Saeideh MomtazSeyed Mohammad Nabavi
Jun 9, 2017·British Journal of Cancer·Jie WangJianxin Jiang
Mar 14, 2017·Pathology, Research and Practice·Dušan BranýMarián Adamkov
Feb 11, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Muthu K ShanmugamGautam Sethi
Jul 22, 2016·Nutrients·Sabrina BimonteFrancesco Izzo
Jan 6, 2011·Molecular Nutrition & Food Research·Jodee Johnson, Elvira Gonzalez de Mejia
Sep 6, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Roxane PaulinSébastien Bonnet
Dec 25, 2013·Beilstein Journal of Organic Chemistry·Silke FelixGerhard Erkel
Jan 3, 2013·Contrast Media & Molecular Imaging·Mingmin TongZhongqiu Wang
Nov 20, 2014·Molecular Biology Reports·Xaioyan XuanQingru Zeng
Sep 19, 2016·Molecular Biology Reports·Balraj Singh Gill Navgeet

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