PMID: 26328442Sep 4, 2015Paper

Curcumin-Loaded Chitosan-Coated Nanoparticles as a New Approach for the Local Treatment of Oral Cavity Cancer

Journal of Nanoscience and Nanotechnology
Leticia MazzarinoElenara Lemos-Senna

Abstract

Mucoadhesive nanoparticles loaded with curcumin were developed as a new approach to deliver curcumin for the local treatment of oral cancer. PCL nanoparticles coated with chitosan displaying different molar masses were prepared by using the nanoprecipitation technique. The mucoadhesive properties of nanoparticle suspensions were demonstrated by their strong ability to interact with the glycoprotein mucin through electrostatic interactions. Similar permeation profiles of curcumin loaded in uncoated and chitosan-coated nanoparticles across porcine esophageal mucosa were verified. Curcumin concentrations retained in the mucosa suggest the possibility of a local effect of the drug. In vitro studies demonstrated that free curcumin.and curcumin loaded into nanoparticles coated with chitosan caused significant reduction of SCC-9 human oral cancer cell viability in a concentration and time-dependent manner. However, no significant cell death was observed after 24 h of treatment with unloaded nanoparticles coated with chitosan. In addition, curcumin-loaded nanoparticles showed reduced cytotoxicity, when compared with the free drug. Therefore, chitosan-coated PCL nanoparticles may be considered a promising strategy to deliver curcumin di...Continue Reading

Citations

Jun 19, 2015·Journal of Pharmaceutical Sciences·Gecioni Loch-NeckelElenara Lemos-Senna
Apr 30, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nadia RuoccoMaria Costantini
May 25, 2016·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Gabriel Álvares BorgesEliete Neves Silva Guerra
Apr 21, 2017·Drug Development and Industrial Pharmacy·Yuri Ikeuchi-TakahashiHiraku Onishi
Jun 27, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Kashappa Goud H Desai
Jan 31, 2019·Journal of Cellular Physiology·Mahsa SahebAmirhossein Sahebkar
Mar 18, 2016·International Journal of Molecular Medicine·Jerzy JankunEwa Skrzypczak-Jankun
Mar 21, 2019·Current Drug Targets·Vandita KakkarIndu Pal Kaur
Feb 27, 2019·Recent Patents on Drug Delivery & Formulation·Himangshu SarmaHemanta K Sharma
Dec 31, 2019·Beilstein Journal of Nanotechnology·Sabrina Barbosa de Souza FerreiraMarcos Luciano Bruschi
Oct 23, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Qinfeng DingKaili Lin
Nov 1, 2020·Translational Oncology·Shilpi GuptaBhudev C Das
Mar 5, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Dwaipayan BhattacharyaRajkumar Banerjee
Apr 1, 2021·Journal of Biomedical Nanotechnology·Giovana Maria Fioramonti CalixtoMarlus Chorilli
May 14, 2021·Bioinorganic Chemistry and Applications·Weiping ZhengChangqing Yuan
Jun 3, 2021·Brazilian Oral Research·Diego Antonio Costa ArantesAline Carvalho Batista

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