Curcumin-loaded lipid-hybridized cellulose nanofiber film ameliorates imiquimod-induced psoriasis-like dermatitis in mice

Biomaterials
Nae-Won KangDae-Duk Kim

Abstract

Cellulose nanofiber (CNF) is an attractive biomaterial given its film-forming properties, excellent mechanical properties and biocompatibility. Herein, CNF film was prepared as a topical drug delivery system by hybridizing curcumin (Cur)-loaded nanostructured lipid carriers (NLCs). NLCs with a mean diameter of ≈500 nm were fabricated by using a solvent diffusion method. The lipid composition of the NLCs was optimized based on the efficiency of Cur delivery to the artificial skin and mechanical strength of the developed films, where a composition containing shea butter and Capmul MCM EP exhibited the highest values of 233.2 ± 96.6 μg/cm2/mg and 4.86 ± 0.14 MPa, respectively. The Cur-loaded lipid-hybridized CNF (lipid@CNF) films with a smooth rather than particle-embedded surface were obtained by vacuum filtration of the NLCs and CNF mixture, which were confirmed by TEM, SEM, AFM, XPS, and FTIR analyses. The Cur-loaded lipid@CNF films exhibited more than 2.0-fold increases in Cur deposition to the epidermis of imiquimod (IMQ)-induced psoriatic mouse compared with the films without lipids, which potentially resulted from the amorphous state of Cur observed in the DSC and PXRD analyses and the permeation-enhancing effect of lipids....Continue Reading

Citations

May 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jeong-Jun LeeJae-Young Lee
Feb 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mahshid Moballegh NaseryGautam Sethi
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Feb 16, 2020·Drug Delivery and Translational Research·Juliana Santos Rosa ViegasMaria Vitória Lopes Badra Bentley
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