Curcumin-loaded self-nanomicellizing solid dispersion system: part I: development, optimization, characterization, and oral bioavailability

Drug Delivery and Translational Research
Ankit ParikhSanjay Garg

Abstract

Curcumin (CUR) is considered as one of the most bioactive molecules ever discovered from nature due to its proven anti-inflammatory and antioxidant in both preclinical and clinical studies. Despite its proven safety and efficacy, the clinical translation of CUR into a useful therapeutic agent is still limited due to its poor oral bioavailability. To overcome its limitation and enhance oral bioavailability by improving its aqueous solubility, stability, and intestinal permeability, a novel CUR formulation (NCF) was developed using the self-nanomicellizing solid dispersion strategy. From the initial screening of polymers for their potential to improve the solubility and stability, Soluplus (SOL) was selected. The optimized NCF demonstrated over 20,000-fold improvement in aqueous solubility as a result of amorphization, hydrogen bonding interaction, and micellization determined using differential scanning calorimetry, X-ray diffraction, scanning electron microscopy, Fourier transform infrared spectroscopy, nuclear magnetic resonance, dynamic light scattering, and transmission electron microscopy. Moreover, the greater stabilizing effect in alkaline pH and light was observed. Furthermore, significant enhancement of dissolution and ...Continue Reading

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Citations

Mar 6, 2019·Phytotherapy Research : PTR·Cheng LiYonggang Wang
Jul 31, 2020·Pharmaceutical Development and Technology·Liyan ZhaoYiling Wu
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Methods Mentioned

BETA
X-ray
nuclear magnetic resonance
transmission electron microscopy
scanning electron microscopy
electron microscopy
infrared spectroscopy
differential scanning calorimetry
scanning

Software Mentioned

Phoenix WinNonlin
analySIS
GraphPad Prism
SOL
TopSpin
CUR

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