Curcumin mitigates mancozeb-induced hepatotoxicity and genotoxicity in rats

Ecotoxicology and Environmental Safety
Taghred M SaberHeba M Abdel-Ghany

Abstract

Mancozeb (MZ) is a widely used ethylene-bis-dithiocarbamate fungicide in agriculture causing hepatoxic and genotoxic effects in rats. Curcumin (CUR) has various pharmacological effects including antioxidant and anti-inflammatory properties. This study investigated the efficacy of CUR in mitigating MZ-induced hepatotoxicity and genotoxicity in rats. Twenty-four male rats were divided into four equal groups; group I (control) was given carboxymethyl cellulose, group II was orally administered CUR (100 mg/kg b.wt), group III was gavaged with MZ (750 mg/kg b.wt), and group IV was co-treated with MZ and CUR at the same doses daily for 10 weeks. As a result, the concurrent treatment with CUR and MZ minimized the increased levels of liver function markers in serum, lipid peroxidation, pro-inflammatory mediators and DNA damage parameters in liver. In addition, CUR administration improved the depleted markers of hepatic antioxidant status in MZ-treated rats. Moreover, CUR protected the liver against the histological alterations elicited by MZ exposure and also, reduced the immunopositive reactivity of pro-apoptotic p53 in cytoplasm of hepatocytes. The present findings suggest that CUR exerts a significant protective effect against MZ-in...Continue Reading

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Citations

Sep 9, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Daowen LiShusheng Tang
Oct 14, 2021·Toxicology and Industrial Health·Mohaddeseh Mohammadi-SardooBagher Amirheidari

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