Curcumin modified silver nanoparticles for highly efficient inhibition of respiratory syncytial virus infection

Nanoscale
Xiao Xi YangCheng Zhi Huang

Abstract

Interactions between nanoparticles and viruses have attracted increasing attention due to the antiviral activity of nanoparticles and the resulting possibility to be employed as biomedical interventions. In this contribution, we developed a very simple route to prepare uniform and stable silver nanoparticles (AgNPs) with antiviral properties by using curcumin, which is a member of the ginger family isolated from rhizomes of the perennial herb Curcuma longa and has a wide range of biological activities like antioxidant, antifungal, antibacterial and anti-inflammatory effects, and acts as reducing and capping agents in this synthetic route. The tissue culture infectious dose (TCID50) assay showed that the curcumin modified silver nanoparticles (cAgNPs) have a highly efficient inhibition effect against respiratory syncytial virus (RSV) infection, giving a decrease of viral titers about two orders of magnitude at the concentration of cAgNPs under which no toxicity was found to the host cells. Mechanism investigations showed that cAgNPs could prevent RSV from infecting the host cells by inactivating the virus directly, indicating that cAgNPs are a novel promising efficient virucide for RSV.

References

Nov 1, 1989·Journal of Ethnopharmacology·K K Soudamini, R Kuttan
Jul 29, 2004·Viral Immunology·Subramaniam KrishnanRobert C Welliver
Jul 1, 2005·Journal of Nanobiotechnology·Jose Luis ElechiguerraMiguel Jose Yacaman
Nov 15, 2007·Molecular Pharmaceutics·Preetha AnandBharat B Aggarwal
Jun 3, 2008·Trends in Biotechnology·Nuria Sanvicens, M Pilar Marco
Mar 3, 2009·Bioorganic & Medicinal Chemistry Letters·James R FuchsPui-Kai Li
Mar 31, 2009·Future Microbiology·Christine M OshanskyRalph A Tripp
Feb 11, 2010·Journal of Nanobiotechnology·Humberto H LaraCristina Rodriguez-Padilla
Aug 20, 2010·Journal of Nanobiotechnology·Janice L SpeshockSaber M Hussain
Jan 5, 2011·Immunology Letters·Susan M BuenoAlexis M Kalergis
Feb 17, 2011·Journal of Agricultural and Food Chemistry· BhawanaNidhi Jain
Sep 29, 2011·Journal of Virological Methods·Dong-xi XiangCong-long Zheng
Oct 26, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Stefania GaldieroMassimiliano Galdiero
Jun 14, 2012·Current Allergy and Asthma Reports·Matthew T Lotz, R Stokes Peebles
Aug 2, 2012·Antimicrobial Agents and Chemotherapy·Manuela DonalisioDavid Lembo
Feb 21, 2013·Nanoscale Research Letters·Yasutaka MoriMasayuki Ishihara
Jul 28, 2013·Journal of Virological Methods·Nana ChenConglong Zheng
Dec 25, 2013·ACS Applied Materials & Interfaces·Matias SametbandRonit Sarid
Jan 3, 2014·Advances in Virology·Swapnil Subhash BawageShree Ram Singh
Jan 17, 2014·Nanoscale·Jonathan VonnemannRainer Haag
Dec 30, 2014·Drug Discovery Today·Liuya WeiGuofang Chen

❮ Previous
Next ❯

Citations

Dec 3, 2016·Clinical Microbiology Reviews·Cameron GriffithsDavid J Marchant
May 30, 2019·Chemical Communications : Chem Comm·Mohammad AzharuddinHirak K Patra
Sep 27, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Hamed NosratiHossein Danafar
Aug 23, 2020·Nanomaterials·Sangiliyandi GurunathanHyuk Song
Sep 4, 2020·ChemPlusChem·Lili LiangGrzegorz Lisak
Oct 5, 2017·World Journal of Gastroenterology : WJG·Zhi-Qiang WeiZhong-Ji Meng
May 28, 2019·Frontiers in Microbiology·Dimas PradityaEike Steinmann
May 20, 2020·Frontiers in Pharmacology·Adhimoolam KarthikeyanTaesun Min
Jan 12, 2019·Critical Reviews in Food Science and Nutrition·Sita Sharan PatelPriyal Jain
Apr 11, 2019·Polymers·Shabnam SattariMohsen Adeli
May 21, 2020·Journal of Translational Medicine·Negar MoradianNima Rezaei
Mar 27, 2020·Journal of Nanobiotechnology·Jinyoung KimSeungjoo Haam
Jun 25, 2018·Global Challenges·Chenchen FengJiangong Liang
Oct 7, 2020·Microorganisms·Morgan R Jennings, Robin J Parks
Oct 9, 2020·Biological Trace Element Research·Kaminee Maduray, Raveen Parboosing
Nov 27, 2020·Nanomaterials·Oana GherasimAlexandru Mihai Grumezescu
Jan 30, 2021·Phytotherapy Research : PTR·Namita Ashish SinghNaresh Kumar
Feb 11, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andrea RónaváriMonika Kiricsi
Nov 5, 2020·Viruses·Morgan R Jennings, Robin J Parks
Jan 14, 2021·Nanomaterials·John Jairo Aguilera-CorreaMaría Vallet-Regí
Dec 10, 2020·Antioxidants·Mahdie RahbanAli A Moosavi-Movahedi
Aug 24, 2020·Pesticide Biochemistry and Physiology·Lin CaiXianchao Sun
Feb 28, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Fernanda PilaquingaMaría de Las Nieves Piña
Feb 23, 2021·Emergent Materials·Farzan Vahedifard, Krishnan Chakravarthy
Mar 20, 2021·International Journal of Biological Macromolecules·Serag Eldin I ElbehairiHani S Hafez
Mar 23, 2021·Journal of Ayurveda and Integrative Medicine·Manjunath B JoshiKapaettu Satyamoorthy
Apr 14, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Douglas DouradoE Sócrates T Egito

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

American Journal of Respiratory and Critical Care Medicine
Marianna Sockrider, Julie Katkin
BioMed Research International
Soheil Zorofchian MoghadamtousiKeivan Zandi
Advances in Experimental Medicine and Biology
B A AskonasM Cannon
© 2022 Meta ULC. All rights reserved