Curcumin Nanoparticles Protect against Isoproterenol Induced Myocardial Infarction by Alleviating Myocardial Tissue Oxidative Stress, Electrocardiogram, and Biological Changes

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Paul-Mihai BoarescuSorana D Bolboacă

Abstract

Curcumin from Curcuma longa is a nutraceutical compound reported to possess strong antioxidant activity that makes it a candidate for use in counteracting oxidative stress-induced damage. The effect of pre-treatment with curcumin nanoparticles (nC) compared to conventional curcumin (Cs) on blood pressure, electrocardiogram, and biological changes on isoproterenol (ISO)-induced myocardial infarction (MI) in rats had been investigated. The Cs doses of 150 and 200 mg/kg bw and all nC doses (100, 150 and 200 mg/kg bw) significantly reduced heart rate before ISO administration and prevented QRS complex enlargement after MI induction (p < 0.026). All doses of Cs and nC prevented prolongation of the QT and QT corrected (QTc) intervals, with better results for higher doses (p < 0.048). The nC solution had more significant results than Cs in all metabolic parameters assessed (lactate dehydrogenase, glycaemia, aspartate transaminase, and alanine transaminase, p < 0.009). nC was more efficient than Cs in limiting myocardial oxidative stress and enhancing antioxidative capacity (p < 0.004). Compared to Cs, nC better prevented myocardial damage extension, reduced interstitial oedema, and inflammation. Curcumin nanoparticles as compared to c...Continue Reading

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Citations

May 16, 2020·Journal of Clinical Medicine·Nóra LampéBéla Juhász
Jun 18, 2020·International Journal of Nanomedicine·Rajasekharreddy PalaSurya M Nauli
Aug 14, 2020·International Journal of Molecular Sciences·Rianthong PhumsuayPasarapa Towiwat
Jul 9, 2020·Therapeutic Advances in Chronic Disease·Sophie MoulinElise Belaidi
Sep 25, 2020·International Journal of Molecular Sciences·Woori JoWoo-Chan Son
Mar 5, 2021·International Journal of Nanomedicine·Izabela Czyzynska-CichonStefan Chlopicki
May 20, 2021·International Journal of Nanomedicine·Mahvash HesariMohammad Abdollahi
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lucileno Rodrigues TrindadeVania Margaret Flosi Paschoalin

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BETA
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