Curcumin potently blocks Kv1.4 potassium channels.

Biochemical and Biophysical Research Communications
Haiyan LiuJ J Enyeart

Abstract

Curcumin, a major constituent of the spice turmeric, is a nutriceutical compound reported to possess therapeutic properties against a variety of diseases ranging from cancer to cystic fibrosis. In whole-cell patch-clamp experiments on bovine adrenal zona fasciculata (AZF) cells, curcumin reversibly inhibited the Kv1.4K+ current with an IC50 of 4.4 microM and a Hill coefficient of 2.32. Inhibition by curcumin was significantly enhanced by repeated depolarization; however, this agent did not alter the voltage-dependence of steady-state inactivation. Kv1.4 is the first voltage-gated ion channel demonstrated to be inhibited by curcumin. Furthermore, these results identify curcumin as one of the most potent antagonists of these K+ channels identified thus far. It remains to be seen whether any of the therapeutic actions of curcumin might originate with its ability to inhibit Kv1.4 or other voltage-gated K+ channel.

References

Feb 14, 1992·Analytical Biochemistry·S P Brooks, K B Storey
Jul 1, 1971·The Journal of General Physiology·E Neher
Aug 1, 1981·Pflügers Archiv : European journal of physiology·O P HamillF J Sigworth
May 1, 1983·The Journal of General Physiology·B P BeanR W Tsien
Aug 4, 1995·European Journal of Pharmacology·T YamagishiN Taira
Aug 1, 1993·The Journal of General Physiology·B Mlinar, J J Enyeart
Jun 28, 1996·The Journal of Biological Chemistry·R S WymoreK G Chandy
Jul 27, 2000·The Journal of Biological Chemistry·J A EnyeartJ J Enyeart
Feb 21, 2002·Molecular Pharmacology·G ScapagniniR Motterlini
Oct 9, 2002·The Journal of Biological Chemistry·John J EnyeartJudith A Enyeart
Mar 7, 2003·American Journal of Physiology. Cell Physiology·Antonny CzarneckiLaurence Bresson-Bepoldin
Sep 5, 2003·Chemistry & Biology·Joong Sup ShimHo Jeong Kwon
Dec 10, 2003·Neuroreport·Bok Hee ChoiSang June Hahn
Apr 24, 2004·Science·Marie E EganMichael J Caplan
Aug 6, 2004·The New England Journal of Medicine·Pamela Zeitlin
Dec 8, 2004·The Journal of Biological Chemistry·Allan L BergerMichael J Welsh
Dec 14, 2004·The Journal of Biological Chemistry·Fusheng YangGregory M Cole
Jan 18, 2006·Life Sciences·Radha K MaheshwariRikhab C Srimal

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Citations

Aug 6, 2009·Journal of Natural Products·Judith A EnyeartJohn J Enyeart
Jun 6, 2013·Journal of Medicinal Food·Mohammad NabiuniJaleel A Miyan
Dec 20, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Umberto BanderaliAru Narendran
Dec 2, 2014·Pharmacology & Therapeutics·Katja SchmitzIrmgard Tegeder
Nov 22, 2011·Toxicology Letters·Chao-Wei HuDe-Li Dong
Nov 27, 2015·Redox Biology·E KheradpezhouhG Y Rychkov
Jun 16, 2015·Epilepsy & Behavior : E&B·Nikolaus J Sucher, Maria C Carles
Nov 8, 2012·Phytotherapy Research : PTR·Yi-Tian LianKun Liu
Apr 15, 2008·Biochemical and Biophysical Research Communications·Judith A EnyeartJohn J Enyeart
Oct 16, 2012·Channels·Ali MobasheriRichard Barrett-Jolley
Nov 14, 2012·Biochemical and Biophysical Research Communications·Da Hye HongWon Sun Park
Dec 31, 2009·Journal of Dental Research·K Y YeonS B Oh
Aug 4, 2018·Journal of Cellular Physiology·Yunes PanahiAmirhossein Sahebkar
Jan 18, 2018·The Journal of Pharmacology and Experimental Therapeutics·Eslam Gaber El NebrisiMurat Oz
Oct 21, 2015·Pharmacological Reports : PR·Iván A Aréchiga-FigueroaAldo A Rodríguez-Menchaca
Oct 22, 2020·Polymers·Zoi TerzopoulouDimitrios Bikiaris

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