Curcumin pretreatment protects against acute acrylonitrile-induced oxidative damage in rats

Toxicology
Xing GuangweiMahendra Bishnoi

Abstract

Acrylonitrile (AN) is widely used in the manufacturing of fibers, plastics and pharmaceuticals. Free radical-mediated lipid peroxidation is implicated in the toxicity of AN. The present study was designed to examine the ability of curcumin, a natural polyphenolic compound, to attenuate acute AN-induced lipid peroxidation in the brain and liver of rats. Male Sprague-Dawley rats were orally administered curcumin at doses of 0 (olive oil control), 50 or 100 mg/kg bodyweight daily for 7 consecutive days. Two hours after the last dose of curcumin, rats received an intraperitoneal injection of 50 mg AN/kg bodyweight. Acute exposure to AN significantly increased the generation of lipid peroxidation products, reflected by high levels of malondialdehyde (MDA) both in the brain and liver. These increases were accompanied by a significant decrease in reduced glutathione (GSH) content and a significant reduction in catalase (CAT) activity in the same tissues. No consistent changes in superoxide dismutase (SOD) activity were observed between the control and AN-treatment groups in both tissues. Pretreatment with curcumin reversed the AN-induced effects, reducing the levels of MDA and enhancing CAT activity and increasing reduced GSH content ...Continue Reading

References

Nov 7, 1977·Biochemical and Biophysical Research Communications·S SzaboR J Jaeger
Feb 15, 1991·Clinica Chimica Acta; International Journal of Clinical Chemistry·L Góth
Jan 1, 1990·Annual Review of Pharmacology and Toxicology·D J Reed
Oct 1, 1989·Journal of Applied Toxicology : JAT·V IvanovR Lauwerys
Jan 1, 1989·Drug Metabolism Reviews·D E NerlandC Babiuk
Oct 12, 1987·Toxicology·J D JohnsonG E Isom
Feb 1, 1974·Forensic Science·B BallantyneP Williams
Aug 1, 1996·Current Opinion in Structural Biology·C OstermeierH Michel
Apr 1, 1997·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·F W BenzJ Li
Aug 26, 1998·Archives of Toxicology·J WhysnerG M Williams
Mar 29, 2000·Forensic Science International : Synergy·H IkegayaT Takatori
Jul 17, 2001·Chemical Research in Toxicology·D E NerlandF W Benz
May 21, 2003·Chemical Research in Toxicology·Donald E NerlandFrederick W Benz
Mar 3, 2004·Human & Experimental Toxicology·Pradeep K ShuklaRikhab C Srimal
May 3, 2005·Archives of Toxicology·Frederick W Benz, Donald E Nerland
Nov 22, 2005·Life Sciences·Sophie P ValentineRhonda J Rosengren
Jan 18, 2006·Life Sciences·Radha K MaheshwariRikhab C Srimal
Mar 21, 2006·Free Radical Biology & Medicine·Yan JiaoSuzy V Torti
Dec 26, 2007·Archives of Physiology and Biochemistry·R FrancoM I Panayiotidis
Aug 30, 2008·Journal of Biochemical and Molecular Toxicology·El-Sayed M El-SayedGamil M Abd-Alla
Oct 7, 2008·Toxicology·E Cristian Campian, Frederick W Benz
Nov 1, 2008·Journal of Bioenergetics and Biomembranes·Peter Brzezinski, Robert B Gennis
Dec 4, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Fatma M El-DemerdashFatma M E Radwan
Apr 21, 2009·Pharmacology, Biochemistry, and Behavior·Pallavi SethiDeepak Sharma
May 26, 2009·Neurochemistry International·Lu RongzhuMichael Aschner

❮ Previous
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Citations

Aug 21, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Wylly Ramsés García-NiñoJosé Pedraza-Chaverrí
Jun 1, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Fahad A Al-Abbasi
Mar 19, 2013·BMC Complementary and Alternative Medicine·Suzy M SalamaShahram Golbabapour
Jun 10, 2011·Neurotoxicity Research·Pooja Khanna SoodBimla Nehru
Feb 2, 2012·Biological & Pharmaceutical Bulletin·An-Chang LiuHong-Xiang Lou
Nov 13, 2015·Archives of Medical Research·Heena TabassumM Irfan Qureshi
Feb 5, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mehmet TokaçNursen Basaran
Sep 11, 2010·International Immunopharmacology·Raghvendra M SrivastavaAshok Khar
Dec 8, 2015·BMC Complementary and Alternative Medicine·Looi Ting YeongNorhafizah Mohtarrudin
Jan 11, 2013·BioFactors·Laura Vera-RamirezJosé L Quiles
Feb 15, 2013·Cell Biochemistry and Function·Mohammad WaseemSuhel Parvez
Apr 4, 2013·Dose-response : a Publication of International Hormesis Society·He YuanqingDejan Milatovic
Apr 23, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Wylly Ramsés García-Niño, José Pedraza-Chaverrí
Dec 19, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mohammad Waseem, Suhel Parvez
Aug 12, 2015·World Journal of Gastrointestinal Pharmacology and Therapeutics·Sael Casas-Grajales, Pablo Muriel
Oct 21, 2018·Environmental Science and Pollution Research International·Pengfei LinJiangyue Wu
Mar 14, 2019·Journal of Basic and Clinical Physiology and Pharmacology·Ebenezer Olatunde FarombiMobolaji Fabusoro
Jun 13, 2020·Chemical Research in Toxicology·Vernon E WalkerJames A Swenberg

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