Curcumin prevents paracetamol-induced liver mitochondrial alterations

The Journal of Pharmacy and Pharmacology
Luis Fernando Granados-CastroJ Pedraza-Chaverrí

Abstract

In the present study was evaluated if curcumin is able to attenuate paracetamol (PCM)-induced mitochondrial alterations in liver of mice. Mice (n = 5-6/group) received curcumin (35, 50 or 100 mg/kg bw) 90 min before PCM injection (350 mg/kg bw). Plasma activity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) was measured; histological analyses were done; and measurement of mitochondrial oxygen consumption, mitochondrial membrane potential, ATP synthesis, aconitase activity and activity of respiratory complexes was carried out. Curcumin prevented in a dose-dependent manner PCM-induced liver damage. Curcumin (100 mg/kg) attenuated PCM-induced liver histological damage (damaged hepatocytes from 28.3 ± 7.7 to 8.3 ± 0.7%) and increment in plasma ALT (from 2300 ± 150 to 690 ± 28 U/l) and AST (from 1603 ± 43 to 379 ± 22 U/l) activity. Moreover, curcumin attenuated the decrease in oxygen consumption using either succinate or malate/glutamate as substrates (evaluated by state 3, respiratory control ratio, uncoupled respiration and adenosine diphosphate/oxygen ratio), in membrane potential, in ATP synthesis, in aconitase activity and in the activity of respiratory complexes I, III and IV. These results indicate tha...Continue Reading

References

Jan 20, 1977·The New England Journal of Medicine·L LyonsA M Sommaripa
Sep 1, 1989·Archives of Biochemistry and Biophysics·R R RamsayS D Nelson
May 1, 1988·Toxicology and Applied Pharmacology·L L MeyersS D Cohen
Feb 1, 1997·Bioscience Reports·P R Gardner
Jan 28, 2005·Journal of Biochemical and Molecular Toxicology·Helieh S OzTheresa S Chen
Aug 29, 2007·Clinics in Liver Disease·Basuki K Gunawan, Neil Kaplowitz
Dec 29, 2007·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Alvin C BronsteinStuart E Heard
Jan 24, 2009·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Ethel A WilhelmCristina W Nogueira
Jan 27, 2009·American Journal of Respiratory Cell and Molecular Biology·Veniamin RatnerVadim S Ten
Jan 6, 2010·Cleveland Clinic Journal of Medicine·Amy SchillingBijan Eghtesad
Sep 2, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mokhtar I YousefLaila A Abdelmegid
Nov 9, 2010·Journal of Clinical Pharmacy and Therapeutics·K ToussaintR B Raffa
Aug 16, 2011·Free Radical Biology & Medicine·Eduardo Molina-JijónJosé Pedraza-Chaverri
Apr 4, 2013·Free Radical Biology & Medicine·Francisco CorreaCecilia Zazueta
Apr 10, 2013·World Journal of Gastroenterology : WJG·Kanjana SomanawatNaruemon Klaikeaw
Aug 21, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Wylly Ramsés García-NiñoJosé Pedraza-Chaverrí
Nov 22, 2013·World Journal of Gastroenterology : WJG·Gang LiQuan Gong
Jan 7, 2014·International Journal of Surgery·Ilker Öngüç AycanMustafa Uğur Yüksel
Feb 4, 2014·European Journal of Pharmacology·Shimaa M ElshazlyWaleed Barakat
Jun 13, 2014·American Journal of Physiology. Cell Physiology·Toan PhamAnthony J R Hickey
Aug 19, 2014·Journal of Biochemical and Molecular Toxicology·Wylly Ramsés García-NiñoJosé Pedraza-Chaverri
Aug 22, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kang Kwang LeeUrs A Boelsterli
Sep 23, 2014·Archiv der Pharmazie·Joyce TrujilloJosé Pedraza-Chaverrí
Dec 30, 2014·Archives of Toxicology·Elizabeth M LancasterAli Zarrinpar
Mar 31, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jung-Ran NohChul-Ho Lee

❮ Previous
Next ❯

Citations

Apr 28, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yi-Lian XieNai-Bin Yang
Jul 12, 2017·World Journal of Gastroenterology : WJG·Alessandra FerramoscaVincenzo Zara
Nov 18, 2017·Drug Development and Industrial Pharmacy·Lu-Lu WangCheng-Lei Zhao
Nov 21, 2017·Environmental Science and Pollution Research International·Zeynab Kh El-Maddawy, Yasser S El-Sayed
Dec 5, 2017·Experimental and Therapeutic Medicine·Aili WangXiaohui Li
Apr 30, 2020·Archives of Biochemistry and Biophysics·Salma M Eraky, Nada F Abo El-Magd
Jan 8, 2021·BMC Complementary Medicine and Therapies·Wei LiMingjiong Ling

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved