Curcumin protects against cigarette smoke-induced cognitive impairment and increased acetylcholinesterase activity in rats

Physiology & Behavior
Jeandre Augusto dos Santos JaquesDaniela Bitencourt Rosa Leal

Abstract

Cigarette smoke, a widely spread habit, is associated with a decline in cognitive function and studies have demonstrated that curcumin (Cur), an Indian spice, possesses a strong neuroprotective potential. Considering the relevance of investigating dietary compounds this study aimed to investigate the effect of Cur on memory and acetylcholinesterase (AChE) activity in brain structures and blood of cigarette smoke-exposed rats. Male Wistar rats were treated with curcumin and cigarette smoke, once a day, 5 days each week, for 30 days. The experimental procedures were divided in two sets of experiments. In the first, the animals were divided into 4 groups: Vehicle (corn oil), Cur 12.5 mg/kg, Cur 25 mg/kg and Cur 50 mg/kg. In the second, the animals were divided into 5 groups: Vehicle (corn oil), Smoke, Smoke plus Cur 12.5 mg/kg, Smoke plus Cur 25 mg/kg and Smoke plus Cur 50 mg/kg. Treatment with Cur significantly prevented the decreased latency and cholinergic alterations in cigarette smoke-exposed rats. These AChE alterations could suggest a role in the memory impairment promoted by cigarette smoke-exposure and point toward the potential of Cur to modulate cholinergic neurotransmission and, consequently, improve cognition deficits...Continue Reading

References

Feb 1, 1991·Planta medica·H P Ammon, M A Wahl
Jun 1, 1980·Toxicology Letters·J O Owasoyo, C A Iramain
Nov 1, 1995·Brain Research. Brain Research Reviews·A Blokland
Oct 26, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·F WorekP Eyer
Apr 15, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·J A CervillaA Mann
Aug 14, 2001·Memórias do Instituto Oswaldo Cruz·C C Araújo, L L Leon
Nov 7, 2002·American Journal of Epidemiology·Sandra KalmijnLenore J Launer
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE
Mar 1, 2005·Journal of Biochemical and Molecular Toxicology·K AnbarasiC S Shyamala Devi
May 11, 2005·Pharmacology, Biochemistry, and Behavior·Amitava DasChandishwar Nath
Dec 3, 2005·Evidence-based Complementary and Alternative Medicine : ECAM·Bhushan PatwardhanNarendra Bhatt
Apr 8, 2006·Psychopharmacology·Gustavo Petri GuerraMaribel Antonello Rubin
May 16, 2006·Human & Experimental Toxicology·Elzbieta NowakowskaJadwiga Jodynis-Liebert
Apr 18, 2007·Nutrition & Metabolism·Renu A Kowluru, Mamta Kanwar
Sep 8, 2007·European Journal of Pharmacology·Anurag Kuhad, Kanwaljit Chopra
Sep 29, 2007·Biochemical Pharmacology·Ajay GoelBharat B Aggarwal
Apr 18, 2008·The Journal of Pharmacology and Experimental Therapeutics·Aynun N BegumSally A Frautschy
Nov 11, 2008·Journal of Alzheimer's Disease : JAD·Chandrashekhar D KamatKenneth Hensley
Apr 21, 2009·Pharmacology, Biochemistry, and Behavior·Pallavi SethiDeepak Sharma
May 23, 2009·Inhalation Toxicology·G R ThoméM R C Schetinger
Dec 23, 2009·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Rahul AgrawalRakesh Shukla
Apr 7, 2010·Naunyn-Schmiedeberg's Archives of Pharmacology·Puneet RinwaNirmal Singh
Sep 21, 2011·Cell Biochemistry and Function·Jeandre Augusto Dos Santos JaquesDaniela Bitencourt Rosa Leal
Dec 6, 2011·Cell Biochemistry and Function·Jeandre Augusto dos Santos JaquesDaniela Bitencourt Rosa Leal
Aug 16, 2016·Genetics and Molecular Research : GMR·L AnP Du

❮ Previous
Next ❯

Citations

Jan 22, 2013·Neurotoxicology·Xiaolan WangXian-Fang Meng
May 20, 2015·Neurobiology of Learning and Memory·Mehmet OzEnver Ahmet Demir
Dec 25, 2012·Neurobiology of Learning and Memory·Jeandre Augusto dos Santos JaquesDaniela Bitencourt Rosa Leal
Oct 4, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Roberto M MacielSonia T A Lopes
Sep 5, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hemant KumarDong-Kug Choi
Jan 19, 2018·Nutrition Reviews·Heather M Francis, Richard J Stevenson
Jul 13, 2020·Cardiovascular Drugs and Therapy·A G ManzoniD B R Leal

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.