Curcumin protects against the oxidative damage induced by the pesticide parathion in the hippocampus of the rat brain

Nutritional Neuroscience
Alejandro A Canales-AguirreAlfredo Feria-Velasco

Abstract

One of the main concerns regarding organophosphate pesticides (OP) is their possible toxic effects. Doses that do not produce acute toxicity are capable of altering the structure and biochemistry of different tissues and organs by production of reactive oxygen species (ROS). Curcumin (CUR) is the main substance in Curcuma longa (Zingiberacea) rhizome that has strong antioxidant activity. However, the neuroprotective properties of curcumin against oxidative stress induced by prolonged exposure to parathion (PAR) is not clear. The present work evaluated the protective effect of curcumin against the oxidative damage induced in the rat hippocampus by the OP PAR. Forty female Wistar rats were distributed in four groups as follows: exposed to PAR by inhalation (PAR group); pre-treated with CUR and then exposed to PAR by inhalation, (CUR + PAR group); exposed to environmental air and treated with CUR in the food (CUR group); and exposed to environmental air (the control group). At the end of the handling process, the concentration of erythrocyte cholinesterase was monitored, as indicator of PAR intoxication and lipoperoxidation, immunohistochemistry for astrocytes, and activated microglia and apoptosis was determined in the hippocampu...Continue Reading

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Citations

Oct 29, 2014·Canadian Journal of Physiology and Pharmacology·Shamsherjit KaurAtish Prakash
Jan 20, 2016·Antioxidants·Ganesh Chandra Jagetia, Golgod Krishnamurthy Rajanikant
Sep 6, 2013·Pharmaceutical Biology·Zahra KiasalariTourandokht Baluchnejadmojarad
May 28, 2020·Pharmacological Reports : PR·Samira EghbaliferizAmirhossein Sahebkar
Aug 8, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sendar Daniel Nery-FloresMariana Chávez Tostado
May 3, 2020·Environmental Science and Pollution Research International·Tahereh FarkhondehSaeed Samarghandian
Apr 6, 2019·Neurotoxicity Research·Faezeh GhasemiAmirhossein Sahebkar
Jan 30, 2019·Oxidative Medicine and Cellular Longevity·Sendar Daniel Nery-FloresAbraham Alberto Ramírez-Mendoza
May 27, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Rabia Shabir AhmadMohammad Hashem Hashempur

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