Curcumin requires tumor necrosis factor α signaling to alleviate cognitive impairment elicited by lipopolysaccharide.

Neuro-Signals
E M KawamotoS Camandola

Abstract

A decline in cognitive ability is a typical feature of the normal aging process, and of neurodegenerative disorders such as Alzheimer's, Parkinson's and Huntington's diseases. Although their etiologies differ, all of these disorders involve local activation of innate immune pathways and associated inflammatory cytokines. However, clinical trials of anti-inflammatory agents in neurodegenerative disorders have been disappointing, and it is therefore necessary to better understand the complex roles of the inflammatory process in neurological dysfunction. The dietary phytochemical curcumin can exert anti-inflammatory, antioxidant and neuroprotective actions. Here we provide evidence that curcumin ameliorates cognitive deficits associated with activation of the innate immune response by mechanisms requiring functional tumor necrosis factor α receptor 2 (TNFR2) signaling. In vivo, the ability of curcumin to counteract hippocampus-dependent spatial memory deficits, to stimulate neuroprotective mechanisms such as upregulation of BDNF, to decrease glutaminase levels, and to modulate N-methyl-D-aspartate receptor levels was absent in mice lacking functional TNFRs. Curcumin treatment protected cultured neurons against glutamate-induced ex...Continue Reading

Citations

Jan 1, 2015·Journal of Neuroinflammation·Paula Fernanda KinoshitaCristoforo Scavone
May 8, 2013·Glia·Emmette R HutchisonMark P Mattson
May 15, 2013·Psychoneuroendocrinology·Ellen E A SimpsonJulie M W Wallace
Jan 2, 2015·Dose-response : a Publication of International Hormesis Society·Mark P Mattson
Aug 28, 2020·Scientific Reports·J A LeiteK Lykke-Hartmann
Dec 15, 2020·Neuroscience and Biobehavioral Reviews·Felipe Figueredo SaviCristiane Ritter

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Methods Mentioned

BETA
Assay
PCR
nuclear translocation

Clinical Trials Mentioned

NCT01068353

Software Mentioned

Videomex Water Maze
Prism
Videomex

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