Curcumin supplementation likely attenuates delayed onset muscle soreness (DOMS)

European Journal of Applied Physiology
Lesley M NicolJohn Kellett

Abstract

Oral curcumin decreases inflammatory cytokines and increases muscle regeneration in mice. To determine effects of curcumin on muscle damage, inflammation and delayed onset muscle soreness (DOMS) in humans. Seventeen men completed a double-blind randomized-controlled crossover trial to estimate the effects of oral curcumin supplementation (2.5 g twice daily) versus placebo on single-leg jump performance and DOMS following unaccustomed heavy eccentric exercise. Curcumin or placebo was taken 2 d before to 3 d after eccentric single-leg press exercise, separated by 14-d washout. Measurements were made at baseline, and 0, 24 and 48-h post-exercise comprising: (a) limb pain (1-10 cm visual analogue scale; VAS), (b) muscle swelling, (c) single-leg jump height, and (d) serum markers of muscle damage and inflammation. Standardized magnitude-based inference was used to define outcomes. At 24 and 48-h post-exercise, curcumin caused moderate-large reductions in pain during single-leg squat (VAS scale -1.4 to -1.7; 90 %CL: ±1.0), gluteal stretch (-1.0 to -1.9; ±0.9), squat jump (-1.5 to -1.1; ± 1.2) and small reductions in creatine kinase activity (-22-29 %; ±21-22 %). Associated with the pain reduction was a small increase in single-leg ju...Continue Reading

References

Dec 1, 1992·British Journal of Sports Medicine·M J Cleak, R G Eston
Dec 1, 1984·Medicine and Science in Sports and Exercise·R B Armstrong
Oct 20, 1995·The Journal of Biological Chemistry·S Singh, B B Aggarwal
Aug 1, 1995·International Journal of Sports Medicine·J MairB Puschendorf
Jun 11, 1999·Journal of Sports Sciences·R Eston, D Peters
Jun 11, 1999·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·P M Clarkson, S P Sayers
Jul 17, 1999·Scandinavian Journal of Medicine & Science in Sports·P H JohanssonB Lindström
Feb 24, 2001·Medicine and Science in Sports and Exercise·B C HarrisonW C Byrnes
Aug 31, 2001·Medicine and Science in Sports and Exercise·K NosakaP Sacco
Sep 19, 2001·JAMA : the Journal of the American Medical Association·A T HirschW R Hiatt
Dec 13, 2002·Journal of Sports Sciences·Christopher Byrne, Roger Eston
Feb 13, 2003·Journal of Strength and Conditioning Research·Declan A J ConnollyMalachy P McHugh
Feb 13, 2003·International Journal of Sports Medicine·D S WilloughbyC Bois
Mar 6, 2003·Sports Medicine·Karoline CheungLinda Maxwell
Dec 4, 2003·Medicine and Science in Sports and Exercise·Darryn S WilloughbyLemuel Taylor
Jan 18, 2006·Life Sciences·Radha K MaheshwariRikhab C Srimal
Mar 24, 2006·Brain, Behavior, and Immunity·David C NiemanJason D Morrow
Jan 31, 2007·British Journal of Sports Medicine·Kylie Louise SellwoodRana Hinman
Mar 3, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J Mark DavisEugene P Mayer
Jun 16, 2007·Advances in Experimental Medicine and Biology·Venugopal P Menon, Adluri Ram Sudheer
Jun 16, 2007·Advances in Experimental Medicine and Biology·Chih-Hung Hsu, Ann-Lii Cheng
Nov 6, 2007·European Journal of Applied Physiology·Joanna VaileBrian Dawson
Mar 19, 2008·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·David S RowlandsMark A Tarnopolsky
Aug 1, 2007·International Journal of Sport Nutrition and Exercise Metabolism·Michael J Saunders
Jul 22, 2008·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Emma CockburnAlan St Clair Gibson
Sep 19, 2008·Chinese Medicine·Hideji ItokawaKuo-Hsiung Lee
Dec 19, 2008·Medicine and Science in Sports and Exercise·William G HopkinsJuri Hanin
Jul 4, 2009·Journal of Applied Physiology·Christina M Dieli-ConwrightE Todd Schroeder
Nov 4, 2009·Scandinavian Journal of Medicine & Science in Sports·G HowatsonS A Howatson
Dec 22, 2009·Sports Medicine·Deborah L Enns, Peter M Tiidus
Mar 12, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·James G Tidball, S Armando Villalta
May 13, 2010·Journal of the International Society of Sports Nutrition·Kerry S KuehlJames C Chesnutt
Sep 24, 2010·Journal of the International Society of Sports Nutrition·Matthew B CookeAlan Hayes
Aug 29, 2012·Oxidative Medicine and Cellular Longevity·Michalis G NikolaidisSteven R McAnulty
Feb 26, 2013·International Journal of Sports Physiology and Performance·Andrea J BraakhuisTimothy E Lowe
Apr 23, 2013·European Journal of Sport Science·Andrea J BraakhuisTim E Lowe
Jul 2, 2014·Journal of the International Society of Sports Nutrition·Franchek DrobnicJosep Tur

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Citations

Apr 7, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·M RondanelliS Perna
Nov 4, 2016·Journal of Exercise Rehabilitation·Jooyoung KimJoohyung Lee
Mar 29, 2018·International Journal of Sport Nutrition and Exercise Metabolism·Ronald J MaughanLars Engebretsen
Jan 19, 2018·International Journal of Sport Nutrition and Exercise Metabolism·Eric S RawsonD Enette Larson-Meyer
Mar 16, 2018·British Journal of Sports Medicine·Ronald J MaughanLars Engebretsen
Dec 20, 2018·Scandinavian Journal of Medicine & Science in Sports·Yoko TanabeHideyuki Takahashi
Mar 1, 2019·Journal of Nutritional Science and Vitaminology·Yoko TanabeHideyuki Takahashi
Jul 31, 2019·Expert Opinion on Drug Metabolism & Toxicology·Ajaikumar B KunnumakkaraBharat B Aggarwal
Jul 29, 2018·British Journal of Sports Medicine·Mayur K RanchordasJoseph T Costello
Dec 15, 2017·The Cochrane Database of Systematic Reviews·Mayur K RanchordasJoseph T Costello
Apr 14, 2020·Critical Reviews in Food Science and Nutrition·Lara Gomes SuhettCeres Mattos Della Lucia
Jul 24, 2020·Journal of the American College of Nutrition·Thomas D CardaciDarryn S Willoughby
Jul 25, 2020·Journal of Dietary Supplements·Alistair R MallardAmanda Rao
Nov 30, 2016·Journal of Cachexia, Sarcopenia and Muscle·Amirhossein SahebkarMaciej Banach
May 7, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·I-Lin WangYi-Ming Chen
Apr 23, 2020·Critical Reviews in Food Science and Nutrition·Marilyn S CampbellBradley S Fleenor
Nov 24, 2020·Critical Reviews in Food Science and Nutrition·Matheus S CostaAlexandre S Silva
Nov 17, 2020·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Kenji DomaJonathan Connor
Nov 3, 2020·Food Science & Nutrition·Fatemeh BabaeiHossein Hosseinzadeh

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