Curcumin suppressed the prostate cancer by inhibiting JNK pathways via epigenetic regulation

Journal of Biochemical and Molecular Toxicology
Wanli ZhaoYuexian Guo

Abstract

Curcumin is a component of turmeric and is isolated from the rhizomes of the plant Curcuma longa. Curcumin was reported to have therapeutic effects on prostate cancer. Yet the molecular mechanism of curcumin remains unclear. In this study, mouse prostate cancer xenograft model was established and subjected to curcumin treatment. GST-c-Jun pull down kinase assays were performed to study the phospho-c-Jun level. Cell Counting Kit-8 assay kit was utilized to detect the cell viability. Immunoblotting and qRT-PCR were performed for target gene expression analysis. Curcumin inhibited growth of prostate cancer in vivo as well as promoted apoptosis of LNCaP cells in vitro. Curcumin inhibited JNK pathway and repressed H3K4me3 in LNCaP cells. Combined use of curcumin and JQ-1 inhibited the prostate cancer efficiently. In conclusion, curcumin inhibits JNK pathway and plays a role in epigenetic regulation of prostate cancer cells by repressing H3K4me3.

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Citations

Mar 3, 2019·International Journal of Molecular Sciences·Teodora CosteaMaria-Magdalena Mocanu
Jan 16, 2020·International Journal of Molecular Sciences·Teodora CosteaMaria-Magdalena Mocanu
Mar 18, 2020·International Journal of Molecular Sciences·Maura CalvaniClaudio Favre
Mar 19, 2019·Frontiers in Genetics·Ángeles Carlos-ReyesCésar López-Camarillo
Nov 22, 2019·Anti-cancer Agents in Medicinal Chemistry·Rumana AhmadArvind K Srivastava
Nov 14, 2020·Biomolecules·Deborah TerminiEvangelia Tsiani
Feb 4, 2021·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Hanwool ParkJeong Gil Leem
Aug 3, 2021·Experimental and Therapeutic Medicine·Liang PanJianming Guo

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