Curcumin Suppresses Hepatic Stellate Cell-Induced Hepatocarcinoma Angiogenesis and Invasion through Downregulating CTGF

Oxidative Medicine and Cellular Longevity
Shan ShaoJianjun Lei

Abstract

Microenvironment plays a vital role in tumor progression; we focused on elucidating the role of hepatic stellate cells (HSCs) in hepatocarcinoma (HCC) aggressiveness and investigated the potential protective effect of curcumin on HSC-driven hepatocarcinoma angiogenesis and invasion. Our data suggest that HSCs increase HCC reactive oxygen species (ROS) production to upregulate hypoxia-inducible factor-1α (HIF-1α) expression to promote angiogenesis, epithelial to mesenchymal transition (EMT) process and invasion. And HSCs could secrete soluble factors, such as interleukin-6 (IL-6), vascular endothelial cell growth factor (VEGF), and stromal-derived factor-1 (SDF-1) to facilitate HCC progression. Curcumin could significantly suppress the above HSC-induced effects in HCC and could abrogate ROS and HIF-1α expression in HCC. HIF-1α or connective tissue growth factor (CTGF) knockdown could abolish the aforementioned curcumin affection. Moreover, CTGF is a downstream gene of HIF-1α. In addition, nuclear factor E2-related factor 2 (Nrf2) and glutathione (GSH) are involved in curcumin protection of HCC. These data indicate that curcumin may induce ROS scavenging by upregulating Nrf2 and GSH, thus inhibiting HIF-1α stabilization to suppre...Continue Reading

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Citations

Oct 18, 2019·Current Molecular Medicine·Milad AshrafizadehSaeed Samarghandian
Apr 27, 2020·Journal of Tissue Engineering and Regenerative Medicine·Zi Guo, Zhaohui Mo
May 8, 2020·Oxidative Medicine and Cellular Longevity·Shan ShaoJianjun Lei
Oct 2, 2020·International Journal of Molecular Sciences·Laura Marinela Ailioaie, Gerhard Litscher
Mar 7, 2021·Antioxidants·Mariapia VairettiClarissa Berardo
Mar 16, 2021·Critical Reviews in Oncology/hematology·RamaRao MallaGanji Purnachandra Nagaraju
Feb 25, 2020·Current Molecular Pharmacology·Mengna WuWenjie Zheng
Apr 4, 2021·Cells·Catia GiovanniniLaura Gramantieri
Nov 11, 2019·Life Sciences·Chelliah SelvamRamasamy Thilagavathi
Dec 29, 2020·Trends in Cancer·Yi-Wen ShenWei-Dong Zhang
Jun 27, 2021·Phytotherapy Research : PTR·Korosh MorshediHamed Mirzaei
Aug 25, 2021·Phytotherapy Research : PTR·Tingting XiaChanggang Sun

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Methods Mentioned

BETA
PCR
Assay
transfect
enzyme-linked immunosorbent assay

Software Mentioned

Prism

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