Curcumin Suppresses microRNA-7641-Mediated Regulation of p16 Expression in Bladder Cancer

The American Journal of Chinese Medicine
Kai WangZhao-Hui Zhong

Abstract

Bladder cancer has a high recurrence rate and requires adjuvant intravesical management after surgery. The use of traditional agents for bladder cancer therapy is constrained by their toxicity and limited efficacy. This emphasizes the need for the development of safer, more effective compounds such as instillation agents. Curcumin is the major component of turmeric, the powdered root of Curcuma longa, which is known for its anti-inflammatory, anti-oxidant and anticancer properties. First, a microarray profiling and qPCR analysis were conducted in the T24 and SV-HUC-1 cell lines. Then, we examined the potential tumorigenicity of miR-7641 in the T24 and SV-HUC-1 cell lines with or without curcumin. Western blot analysis showed that p16 is a target of miR-7641 in T24 cells. We found that, for the first time, curcumin directly downregulates a tumor-promoting microRNA (miRNA), miR-7641, in bladder cancer, which has tumor-promoting characteristics. Curcumin induces the downregulation of miR-7641 and subsequent upregulation of p16 which is a target of miR-7641 at the post-transcriptional level, which leads to the decreased invasion and increased apoptosis of bladder cancer cells. This is the first report to show a direct effect of cur...Continue Reading

References

Jul 13, 2011·Molecular and Cellular Biochemistry·Shao-zhuang DongSai Nie
Aug 13, 2011·Cancer Prevention Research·Sharanjot SainiRajvir Dahiya
Aug 11, 2012·European Urology·Maximilian BurgerYair Lotan
Jun 14, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Qiong LuXuan Zhu
Aug 1, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qing-Yong ChenLi Yan
Jun 28, 2016·Lancet·Ashish M KamatWassim Kassouf
Jul 28, 2016·Reviews of Physiology, Biochemistry and Pharmacology·Amir Abbas MomtaziAmirhossein Sahebkar
Nov 17, 2016·The American Journal of Chinese Medicine·Zhi-Yong WangHui-Ming Yang
Dec 23, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ali MohammadiBehzad Baradaran
Jan 7, 2017·BJU International·Solomon L WolduYair Lotan
Mar 23, 2017·Gene·Yunliang GaoYongbao Wei
Jun 16, 2017·Journal of Cellular Physiology·Hamed MirzaeiMahmoud Reza Jaafari
Feb 10, 2018·Current Vascular Pharmacology·Abolfazl ShakeriAmirhossein Sahebkar

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Citations

Apr 25, 2019·Journal of Cellular Physiology·Yezhou LiDexin Yin
May 30, 2020·International Journal of Molecular Sciences·Jochen RutzBorna Relja
Feb 6, 2020·Anti-cancer Agents in Medicinal Chemistry·Milad AshrafizadehAmirhossein Sahebkar
Nov 22, 2019·Anti-cancer Agents in Medicinal Chemistry·Rumana AhmadArvind K Srivastava
Dec 4, 2019·The American Journal of Chinese Medicine·Yonghui YuChenglong Wang
Jan 4, 2020·Journal of Cellular Biochemistry·Liangyuan ChenFalin Chen
May 28, 2019·Journal of Cancer Research and Clinical Oncology·Marek SamecDietrich Büsselberg
Oct 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Seung Wan SonJong Kook Park
Jan 28, 2021·The Kaohsiung Journal of Medical Sciences·Qi JiangXiong-Wen Zhou
Feb 24, 2021·Cell Communication and Signaling : CCS·Songjie ShenQiang Sun
Apr 28, 2021·Critical Reviews in Food Science and Nutrition·Fatemeh SadoughiBahman Yousefi
Jul 30, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Beilei ZhangFu Wang
Aug 8, 2021·International Journal of Molecular Sciences·Paulina WignerJoanna Saluk-Bijak
Aug 10, 2020·Anti-cancer Agents in Medicinal Chemistry·Mohammad H PourhanifehHamed Mirzaei

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