Curdlan blocks the immune suppression by myeloid-derived suppressor cells and reduces tumor burden

Immunologic Research
Ke RuiShengjun Wang

Abstract

Tumor-elicited immunosuppression is one of the essential mechanisms for tumor evasion of immune surveillance. It is widely thought to be one of the main reasons for the failure of tumor immunotherapy. Myeloid-derived suppressor cells (MDSCs) comprise a heterogeneous population of cells that play an important role in tumor-induced immunosuppression. These cells expand in tumor-bearing individuals and suppress T cell responses via various mechanisms. Curdlan, the linear (1 → 3)-β-glucan from Agrobacterium, has been applied in the food industry and other sectors. The anti-tumor property of curdlan has been recognized for a long time although the underlying mechanism still needs to be explored. In this study, we investigated the effect of curdlan on MDSCs and found that curdlan could promote MDSCs to differentiate into a more mature state and then significantly reduce the suppressive function of MDSCs, decrease the MDSCs in vivo and down-regulate the suppression in tumor-bearing mice, thus leading to enhanced anti-tumor immune responses. We, therefore, increase the understanding of further mechanisms by which curdlan achieves anti-tumor effects.

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Citations

Mar 16, 2017·European Journal of Immunology·Tobias HaasJürgen Ruland
Sep 18, 2018·Expert Opinion on Biological Therapy·Priscilla de GraaffReno Debets
Jun 17, 2020·Preparative Biochemistry & Biotechnology·Jie WanXuexia Yang
Mar 7, 2020·Journal of Ovarian Research·Shahla ChaichianZatollah Asemi
Oct 13, 2020·Pharmacology & Therapeutics·Laura MasuelliRoberto Bei
May 1, 2021·Nutrients·Shafaque RahmanSigrid E M Heinsbroek
Oct 9, 2021·Signal Transduction and Targeted Therapy·Kai LiYongsheng Wang

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