PMID: 16522258Mar 9, 2006Paper

Current advances and challenges in HIV-1 vaccines

Current HIV/AIDS Reports
Isaac R Rodriguez-ChavezM Patricia D'Souza

Abstract

Recent advances in science, which have aided HIV-1 vaccine development, include an improved understanding of HIV-1 envelope structure and function, expansion of the pipeline with innovative vaccine strategies, promising multi-gene and multi-clade vaccines that elicit cellular immunity, conduct of clinical trials in a global network, and development of validated techniques that enable simultaneous measurement of multiple T cell vaccine-induced immune responses in humans. A common feature of several preventive vaccine strategies now in early clinical trials is their ability in nonhuman primates to attenuate clinical disease rather than completely prevent HIV-1 infection. One vaccine concept has been tested in large-scale clinical trials, two are currently in efficacy trials, and one more is poised to enter efficacy trial in the next few years. Simultaneously, expanded efforts continue to identify new designs that induce mucosal immunity as well as broadly neutralizing antibodies.

References

Jul 1, 1996·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·A BolmstedtS Olofsson
Jan 10, 1997·Science·J BalzariniJ P Kleim
Jan 20, 1997·The Journal of Experimental Medicine·L MuseyM J McElrath
Apr 23, 1999·Journal of Reproductive Immunology·J A HoxieT J Matthews
Sep 25, 1999·The Journal of Biological Chemistry·T MirzabekovJ Sodroski
Jan 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·R KaulS L Rowland-Jones
Aug 2, 2000·Proceedings of the National Academy of Sciences of the United States of America·D G MyszkaM L Doyle
Mar 21, 2003·Nature·Xiping WeiGeorge M Shaw
Jul 5, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Bhupat D RawalMichael P Busch
Jul 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Luwy MuseyM Juliana McElrath
Jul 10, 2004·AIDS Research and Human Retroviruses·James M SmithHarriet L Robinson
Sep 15, 2004·The Journal of Experimental Medicine·Jason M BrenchleyDaniel C Douek
Feb 3, 2005·The Journal of Infectious Diseases·Neil M FlynnUNKNOWN rgp120 HIV Vaccine Study Group

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Citations

May 16, 2008·AIDS Patient Care and STDs·Graeme MoyleChristos Tsoukas
Jul 1, 2006·Current Opinion in HIV and AIDS·Pierre-Alexandre BartGiuseppe Pantaleo
Oct 9, 2009·International Reviews of Immunology·Antonella CaputoBarbara Ensoli
Apr 4, 2007·Expert Review of Anti-infective Therapy·Chuen-Yen LauMargaret I Johnston
Jan 19, 2016·Biologicals : Journal of the International Association of Biological Standardization·Rebecca L SheetsIvana Knezevic
Jan 7, 2016·Biologicals : Journal of the International Association of Biological Standardization·Rebecca L SheetsIvana Knezevic
Dec 17, 2011·Trends in Molecular Medicine·Su M Metcalfe, Tarek M Fahmy
Mar 29, 2011·Advances in Dental Research·S J ChallacombeS M Wahl

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