Current advances in the algae-made biopharmaceuticals field

Expert Opinion on Biological Therapy
Sergio Rosales-MendozaBernardo Bañuelos-Hernandez

Abstract

Introduction: The biopharmaceuticals industry demands new production platforms to address several challenges; such as cost reduction to make biologics accessible in low-income countries, safety enhancement of the product, development of products administered by noninvasive routes, and expansion of potential biosimilars and biobetters. Microalgae are emerging hosts for biopharmaceuticals production with the potential to meet such requirements.Areas covered: Nowadays successful cases on the production of vaccines, antibodies, antimicrobial peptides, growth factors/cytokines, and hormones in algae have been reported. This review comprises an updated outlook covering protein expression strategies, a compilation of functional biopharmaceuticals produced in algae, and companies investing in this technology.Expert opinion: Key perspectives for the field include optimizing yields, scaling up production and completing preclinical trials. The experience from the field of plant-made biopharmaceuticals is commented as a key reference that will aid in the development of the algae-made biopharmaceuticals field.

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Citations

Sep 10, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sergio Rosales-MendozaSornkanok Vimolmangkang
Jan 5, 2021·Frontiers in Plant Science·Elodie Mathieu-RivetMuriel Bardor
Oct 31, 2020·Frontiers in Bioengineering and Biotechnology·Myra N ChávezJörg Nickelsen
Mar 7, 2021·Carbohydrate Polymers·Rodolphe DumontierMuriel Bardor
Apr 27, 2021·Frontiers in Plant Science·Ashwini MallaSornkanok Vimolmangkang
Jun 1, 2021·Frontiers in Plant Science·Karen Lizbeth Reyes-BarreraÁngel Gabriel Alpuche-Solís
Jun 29, 2021·Biotechnology Advances·Sarah D'AdamoRene H Wijffels
Aug 23, 2021·Microbial Cell Factories·Ranjna SirohiSang Jun Sim

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