Current advances of pharmacological properties of 7-chloro-4-(phenylselanyl) quinoline: Prevention of cognitive deficit and anxiety in Alzheimer's disease model

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Mikaela P PinzCristiane Luchese

Abstract

This study investigated the effect of 7-chloro-4-(phenylselanyl) quinoline (4-PSQ) at a dose of 1 mg/kg in memory impairment and anxiety in an Alzheimer's disease (AD) model induced by amyloid β-peptide (Aβ) (fragment 25-35) in mice. The involvement of acetylcholinesterase (AChE) activity and lipid peroxidation in hippocampus and cerebral cortex was evaluated. Male Swiss mice were pretreated with 4-PSQ (1 mg/kg, intragastrically (i.g.), daily) for fourteen days. Thirty minutes after the first treatment with 4-PSQ, the animals received a single injection of Aβ (3 nmol/3 μl/per site, intracerebroventricular (i.c.v.)). Mice were submitted to the behavioral tasks (open-field, elevated plus maze, Barnes maze, object recognition and location, and step-down inhibitory avoidance tests) from the fifth day onwards. On the fifteenth day, blood was removed for analysis of biochemical markers (glucose, triglycerides, urea, aspartate (AST) and alanine (ALT) aminotrasferases), and cerebral cortex and hippocampus for determination of AChE activity and thiobarbituric acid reactive species (TBARS) levels. Aβ caused memory impairment, anxiogenic behavior, increased AChE activity in the cerebral structures and TBARS levels in the cerebral cortex. ...Continue Reading

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Citations

Nov 23, 2019·Organic & Biomolecular Chemistry·José M da C Tavares JuniorNelson L C Domingues
Dec 11, 2019·Canadian Journal of Physiology and Pharmacology·Ethel A WilhelmCristiane Luchese
Aug 19, 2020·Canadian Journal of Physiology and Pharmacology·Briana B LemosEthel A Wilhelm
Mar 20, 2021·Psychopharmacology·Karline C RodriguesCristiane Luchese
Jun 7, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Guilherme T VossEthel A Wilhelm
May 21, 2021·Canadian Journal of Physiology and Pharmacology·Ketlyn P da MottaEthel A Wilhelm

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