Feb 13, 2019

Current advances of tubulin inhibitors as dual acting small molecules for cancer therapy

Medicinal Research Reviews
Kinsie E ArnstDuane D Miller

Abstract

Microtubule (MT)-targeting agents are highly successful drugs as chemotherapeutic agents, and this is attributed to their ability to target MT dynamics and interfere with critical cellular functions, including, mitosis, cell signaling, intracellular trafficking, and angiogenesis. Because MT dynamics vary in the different stages of the cell cycle, these drugs tend to be the most effective against mitotic cells. While this class of drug has proven to be effective against many cancer types, significant hurdles still exist and include overcoming aspects such as dose limited toxicities and the development of resistance. Newer generations of developed drugs attack these problems and alternative approaches such as the development of dual tubulin and kinase inhibitors are being investigated. This approach offers the potential to show increased efficacy and lower toxicities. This review covers different categories of MT-targeting agents, recent advances in dual inhibitors, and current challenges for this drug target.

  • References198
  • Citations2

Citations

Mentioned in this Paper

Angiogenic Process
Inhibitors
Modulation by Symbiont of Host Intracellular Transport
Intercellular Communication Process
Toxic Effect
Cancer Treatment
Pharmacologic Substance
Cell Cycle
Resistance Process
Tubulin

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