Jul 10, 2019

Current and emerging avenues for Alzheimer's disease drug targets

Journal of Internal Medicine
R Loera-ValenciaB Winblad

Abstract

Alzheimer's disease (AD), the most frequent cause of dementia, is escalating as a global epidemic, and so far, there is neither cure nor treatment to alter its progression. The most important feature of the disease is neuronal death and loss of cognitive functions, caused probably from several pathological processes in the brain. The main neuropathological features of AD are widely described as amyloid beta (Aβ) plaques and neurofibrillary tangles of the aggregated protein tau, which contribute to the disease. Nevertheless, AD brains suffer from a variety of alterations in function, such as energy metabolism, inflammation and synaptic activity. The latest decades have seen an explosion of genes and molecules that can be employed as targets aiming to improve brain physiology, which can result in preventive strategies for AD. Moreover, therapeutics using these targets can help AD brains to sustain function during the development of AD pathology. Here, we review broadly recent information for potential targets that can modify AD through diverse pharmacological and nonpharmacological approaches including gene therapy. We propose that AD could be tackled not only using combination therapies including Aβ and tau, but also considering...Continue Reading

  • References395
  • Citations4

References

  • References395
  • Citations4

Mentioned in this Paper

Research
Vascular Motor Function
Cholesterol Metabolic Process
Genes
Neurofibrillary Degeneration (Morphologic Abnormality)
Combination Drug Therapy
Energy Metabolism
Brain
Alzheimer's Disease
Neuronal Plasticity

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