Current and emerging basic science concepts in bone biology: implications in craniofacial surgery

The Journal of Craniofacial Surgery
Adam J OppenheimerSteven R Buchman

Abstract

Ongoing research in bone biology has brought cutting-edge technologies into everyday use in craniofacial surgery. Nonetheless, when osseous defects of the craniomaxillofacial skeleton are encountered, autogenous bone grafting remains the criterion standard for reconstruction. Accordingly, the core principles of bone graft physiology continue to be of paramount importance. Bone grafts, however, are not a panacea; donor site morbidity and operative risk are among the limitations of autologous bone graft harvest. Bone graft survival is impaired when irradiation, contamination, and impaired vascularity are encountered. Although the dura can induce calvarial ossification in children younger than 2 years, the repair of critical-size defects in the pediatric population may be hindered by inadequate bone graft donor volume. The novel and emerging field of bone tissue engineering holds great promise as a limitless source of autogenous bone. Three core constituents of bone tissue engineering have been established: scaffolds, signals, and cells. Blood supply is the sine qua non of these components, which are used both individually and concertedly in regenerative craniofacial surgery. The discerning craniofacial surgeon must determine the ...Continue Reading

References

Sep 1, 1977·Journal of Biomedical Materials Research·M Chvapil
Dec 1, 1987·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·L M WolfordJ M Hartog
Nov 12, 1965·Science·M R Urist
Dec 1, 1984·The Journal of Surgical Research·J B MullikenJ Glowacki
Jul 1, 1997·Plastic and Reconstructive Surgery·B L EppleyR J Havlik
Mar 3, 1998·The Journal of Craniofacial Surgery·J W Polley, A A Figueroa
Feb 15, 2001·Plastic and Reconstructive Surgery·A K Gosain, UNKNOWN Plastic Surgery Educational Foundation DATA Committee
Jun 20, 2001·Trends in Biotechnology·R H Li, J M Wozney
Oct 18, 2003·Science·David A Williams, Christopher Baum
Sep 28, 2007·Plastic and Reconstructive Surgery·James E ZinsFrank A Papay
Jan 24, 2009·The Journal of Craniofacial Surgery·Harvey Chim, Arun K Gosain
Jul 7, 2009·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Erik Neovius, Thomas Engstrand
Nov 26, 2009·The Journal of Craniofacial Surgery·Daniel A Peters, Douglas J Courtemanche
Jan 6, 2010·Plastic and Reconstructive Surgery·Scott P Bartlett, Roy Foo
Sep 21, 2010·Facial Plastic Surgery : FPS·Christopher M Runyan, Jesse A Taylor
Sep 22, 2010·The Journal of Craniofacial Surgery·Jesse A Taylor
Nov 1, 2008·Craniomaxillofacial Trauma & Reconstruction·Adam J OppenheimerSteven R Buchman

❮ Previous
Next ❯

Citations

May 1, 2013·Plastic and Reconstructive Surgery·Kristoffer B SuggSteven R Buchman
May 15, 2015·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Abigail J FongLawrence J Gottlieb
Apr 25, 2006·The Journal of Hand Surgery·Richard A RogachefskyBrooks Applegate
Aug 16, 2016·Journal of Tissue Engineering and Regenerative Medicine·Siddharth ShanbhagAndreas Stavropoulos
Jan 10, 2019·Journal of Clinical Periodontology·Siddharth ShanbhagKamal Mustafa
May 23, 2015·Craniomaxillofacial Trauma & Reconstruction·Sandi LamRussell Reid
May 15, 2015·The Journal of Craniofacial Surgery·Oscar J ManriqueMark Smith
Jun 11, 2014·The Journal of Craniofacial Surgery·Massimo RobionyMassimo Politi
May 29, 2014·Plastic and Reconstructive Surgery·Christian J VerclerSteven R Buchman
Jul 3, 2013·Clinical Implant Dentistry and Related Research·Siddharth Shanbhag, Vivek Shanbhag
May 10, 2013·Annals of Plastic Surgery·James CrayJoseph E Losee
Jan 1, 2014·Aesthetic Plastic Surgery·Alyssa Reiffel GolasJason A Spector

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.